Document Detail

Reversed effects between crude and processed ginger extracts on PGF2 alpha-induced contraction in mouse mesenteric veins.
MedLine Citation:
PMID:  2770060     Owner:  NLM     Status:  MEDLINE    
The effects of crude and processed ginger extracts and pungent components, S-(+)-[6]-gingerol and [6]-shogaol, on noradrenaline (NA)- and prostaglandin (PG) F2 alpha-induced contraction were investigated using mouse mesenteric veins. Both spicy constituents inhibited the contractile responses to NA. Crude ginger extract and S-(+)-[6]-gingerol potentiated the PGF2 alpha-induced contraction, whereas processed ginger extract and [6]-shogaol inhibited the contraction.
L R Pancho; I Kimura; R Unno; M Kurono; M Kimura
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  50     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-28     Completed Date:  1989-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  243-6     Citation Subset:  IM    
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
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MeSH Terms
Catechols / pharmacology
Dinoprost / pharmacology*
Fatty Alcohols / pharmacology
Mesenteric Veins / drug effects
Muscle Contraction / drug effects
Muscle, Smooth, Vascular / drug effects*
Plant Extracts / pharmacology*
Reg. No./Substance:
0/Catechols; 0/Fatty Alcohols; 0/Plant Extracts; 1391-73-7/gingerol; 551-11-1/Dinoprost; 555-66-8/shogaol

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