| Reversed association between levels of prostate specific antigen and levels of blood cadmium and urinary cadmium. | |
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MedLine Citation:
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PMID: 21272915 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Prostate cancer associated with cadmium exposure may indicate a link between prostate specific antigen (PSA) and levels of blood cadmium (BCd) and urinary cadmium (UCd). Thus, these associations were investigated. We recruited 295 men, 50years of age and above from a health check-up program at a health center as subjects of the study. They completed a self-reported questionnaire and provided fasting samples of blood and urine for cadmium assay. The assay was performed using atomic absorption spectrophotometry. Blood samples were also collected for the assays of total cholesterol and high-density lipoprotein measures. The means of BCd and UCd increased with age and the means of all subjects were 1.19±1.04μgL(-1) and 1.37±1.76μgg(-1) creatinine, respectively. The PSA levels were positively associated with the lipid levels, but reversely associated with BCd and UCd levels. The multivariate logistic regression analysis showed that men with PSA⩾4.0ngmL(-1) had an odds ratio (OR) of 0.4 (95% CI=0.1-0.9) to have BCd>0.49μgL(-1), and an OR of 0.4 (95% CI=0.2-1.0) to have UCd>0.45μgg(-1) creatinine. In conclusion, the PSA levels are reversely associated with BCd and UCd levels. |
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Authors:
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Chin-Ching Wu; Yeong S Pu; Hsi-Chin Wu; Chun-Yuh Yang; Yi-Chun Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-25 |
Journal Detail:
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Title: Chemosphere Volume: - ISSN: 1879-1298 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Public Health and Division of Urology, China Medical University and Hospital, Taichung 404, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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