Document Detail

Reversed Glucose and Fatty Acids Transporter Expression in Human Endometrial Cancer.
MedLine Citation:
PMID:  22351475     Owner:  NLM     Status:  Publisher    
Cancer cells exhibit accelerated rates of metabolism favoring glucose over fatty acid (FA) utilization. For both energy substrates, protein-mediated transport plays an essential role in facilitating glucose or FA movement across plasma membrane into the cells. Scarce data exist regarding the expression of glucose and/or FA transporter in cancer tissue. Therefore, we examined glucose (GLUT-1, GLUT-3, GLUT-4) and FA (FAT/CD36, FABPpm, FATP-1) transporter expressions at the protein and post-transcript (mRNA) levels in 35 endometrial carcinomas (G1, type endometrioid, FIGO I) and compared them with normal endometrial mucosa (n=10). Endometrial cancer tissue had significantly greater protein expression of GLUT-1, GLUT-3, and GLUT-4 (+ 40%; + 20%; + 24%; p<0.05, respectively) and, conversely, lower fatty acid (FAT/CD36 and FATP-1) transporter expression ( - 25%; p<0.05 and  - 15%, p>0.05 respectively). Interestingly, mRNA content closely mirrors the changes, but only for glucose transporters and not fatty acid transporters. These results suggest the presence of metabolic switch of energy utilization in endometrial cancers favoring glucose consumption as the major source of energy.
P Knapp; A Chabowski; D Harasiuk; J Górski
Related Documents :
12005035 - Influence of dietary protein type and iron source on the absorption of amino acids and ...
16969125 - The biochemical changes associated with phytic acid on induced breast proliferative les...
18540615 - Hydrolysis and adsorption of cyhalofop-butyl and cyhalofop-acid on soil colloids.
8475005 - Protein, calcium, iron, and amino acid content of selected wild and domesticated cultiv...
12865265 - Conditions for acid catalysed luminal nitrosation are maximal at the gastric cardia.
2335515 - Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-coa: chol...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-20
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme     Volume:  -     ISSN:  1439-4286     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Department of Gynecology, Medical University of Białystok, Białystok, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of Low and High Dose Cosyntropin Stimulation Tests in the Diagnosis of Adrenal Insufficie...
Next Document:  Effects of Erythropoietin on Glucose Metabolism.