Document Detail

Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage.
MedLine Citation:
PMID:  11896279     Owner:  NLM     Status:  MEDLINE    
Host-pathogen interactions are often driven by mechanisms that promote genetic variability. We have identified a group of temperate bacteriophages that generate diversity in a gene, designated mtd (major tropism determinant), which specifies tropism for receptor molecules on host Bordetella species. Tropism switching is the result of a template-dependent, reverse transcriptase-mediated process that introduces nucleotide substitutions at defined locations within mtd. This cassette-based mechanism is capable of providing a vast repertoire of potential ligand-receptor interactions.
Minghsun Liu; Rajendar Deora; Sergei R Doulatov; Mari Gingery; Frederick A Eiserling; Andrew Preston; Duncan J Maskell; Robert W Simons; Peggy A Cotter; Julian Parkhill; Jeff F Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  295     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-15     Completed Date:  2002-04-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2091-4     Citation Subset:  IM    
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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MeSH Terms
Bacteriophages / enzymology,  genetics*,  physiology*,  ultrastructure
Bordetella bronchiseptica / genetics,  metabolism,  virology*
Genes, Viral*
Genetic Variation
Genome, Viral
RNA-Directed DNA Polymerase / genetics,  metabolism*
Receptors, Virus / metabolism
Repetitive Sequences, Nucleic Acid
Templates, Genetic
Grant Support
Reg. No./Substance:
0/Receptors, Virus; EC DNA Polymerase
Comment In:
Science. 2002 Mar 15;295(5562):2031-2   [PMID:  11896263 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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