| Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage. | |
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MedLine Citation:
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PMID: 11896279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Host-pathogen interactions are often driven by mechanisms that promote genetic variability. We have identified a group of temperate bacteriophages that generate diversity in a gene, designated mtd (major tropism determinant), which specifies tropism for receptor molecules on host Bordetella species. Tropism switching is the result of a template-dependent, reverse transcriptase-mediated process that introduces nucleotide substitutions at defined locations within mtd. This cassette-based mechanism is capable of providing a vast repertoire of potential ligand-receptor interactions. |
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Authors:
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Minghsun Liu; Rajendar Deora; Sergei R Doulatov; Mari Gingery; Frederick A Eiserling; Andrew Preston; Duncan J Maskell; Robert W Simons; Peggy A Cotter; Julian Parkhill; Jeff F Miller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 295 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-15 Completed Date: 2002-04-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 2091-4 Citation Subset: IM |
Affiliation:
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Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteriophages
/
enzymology,
genetics*,
physiology*,
ultrastructure Bordetella bronchiseptica / genetics, metabolism, virology* Genes, Viral* Genetic Variation Genome, Viral Mutation RNA-Directed DNA Polymerase / genetics, metabolism* Receptors, Virus / metabolism Repetitive Sequences, Nucleic Acid Templates, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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AI38417/AI/NIAID NIH HHS; AI43986/AI/NIAID NIH HHS; GM-08042/GM/NIGMS NIH HHS; T32A107323//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Virus; EC 2.7.7.49/RNA-Directed DNA Polymerase |
| Comments/Corrections | |
Comment In:
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Science. 2002 Mar 15;295(5562):2031-2
[PMID:
11896263
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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