Document Detail

Reverse redistribution in Tl-201 stress-redistribution myocardial scintigraphy. Effect of rest reinjection.
MedLine Citation:
PMID:  7842588     Owner:  NLM     Status:  MEDLINE    
To clarify the clinical significance of Tl-201 reverse redistribution (RR), 33 patients with chronic coronary artery disease (CAD) underwent stress-redistribution Tl-201 cardiac imaging with rest reinjection, coronary arteriography, and 2D-echocardiography. Rest Tc-99m MIBI scintigraphy was also performed in 27 of the 33 patients. A total of 495 segments were analyzed for Tl-201 scintigraphy (405 for Tc-99m MIBI). Each segment was assigned to one of the major coronary artery territories. Two patterns of RR were identified; 1) pattern A (RR-A) showed normal Tl-201 uptake on stress images and lower than normal on redistribution images, and 2) pattern B (RR-B) showed lower than normal Tl-201 uptake on stress images with further decrease on redistribution images. The RR phenomenon was found in 46 (9% of the total) segments; 25 with RR-A and 21 with RR-B. Reverse redistribution pattern A segments had lower Tc-99m MIBI uptake (84 +/- 9% versus 92 +/- 10%, P < 0.0001) and a higher percentage of stenosed coronary arteries (80% versus 49%, P < 0.05) compared to normal segments (n = 204, 41% of the total). No difference in wall motion was observed between RR-A and normal segments. Of the 25 segments with RR-A, 14 showed enhanced Tl-201 uptake after reinjection (Re+) and 11 remained unchanged after reinjection (Re-). Segments that were Re- showed significantly (P < 0.05) lower Tc-99m MIBI uptake (79 +/- 9%) compared to Re+ segments (87 +/- 8%) and normal segments (92 +/- 10%).(ABSTRACT TRUNCATED AT 250 WORDS)
L Pace; A Cuocolo; E Nicolai; M Imbriaco; S Maurea; A Nappi; B Ricciardelli; M Salvatore
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  19     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-03-07     Completed Date:  1995-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  956-61     Citation Subset:  IM    
Cattedra di Medicina Nucleare, Università Federico II, Napoli, Italy.
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MeSH Terms
Coronary Angiography
Coronary Disease / diagnosis,  radionuclide imaging*
Exercise Test
Heart / radionuclide imaging*
Heart Catheterization
Middle Aged
Technetium Tc 99m Sestamibi / diagnostic use
Thallium Radioisotopes / diagnostic use*
Time Factors
Reg. No./Substance:
0/Thallium Radioisotopes; 109581-73-9/Technetium Tc 99m Sestamibi

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