| Reverse engineering models of cell cycle regulation. | |
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MedLine Citation:
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PMID: 18783174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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From general considerations of the basic physiological properties of the cell division cycle, we deduce what the dynamical properties of the underlying molecular control system must be. Then, taking a few hints from the biochemistry of cyclin-dependent kinases (the master regulators of the eukaryotic cell cycle), we guess what molecular mechanisms must be operating to produce the desired dynamical properties of the control system. |
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Authors:
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Attila Csikász-Nagy; Béla Novák; John J Tyson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 641 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-09-11 Completed Date: 2008-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 88-97 Citation Subset: IM |
Affiliation:
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Materials Structure and Modeling Research Group of the Hungarian Academy of Sciences, Budapest, Hungary. csikasz@mail.bme.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Clocks Biomedical Engineering Cell Cycle / physiology* Metabolic Networks and Pathways Models, Biological* Saccharomyces cerevisiae / cytology, physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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