| Reverse the curse--the role of deubiquitination in cell cycle control. | |
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MedLine Citation:
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PMID: 18346885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reversible protein ubiquitination is a crucial mechanism regulating the progression through the eukaryotic cell cycle. Ubiquitin-dependent signaling is terminated by specific deubiquitinating enzymes (DUBs), which now are known to be integral components of the core cell cycle machinery and cell cycle checkpoints. The importance of DUBs for cell cycle control is underscored by their frequent misregulation in cancer. Here, we discuss the role of deubiquitinating enzymes in controlling proliferation. |
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Authors:
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Ling Song; Michael Rape |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2008-03-17 |
Journal Detail:
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Title: Current opinion in cell biology Volume: 20 ISSN: 0955-0674 ISO Abbreviation: Curr. Opin. Cell Biol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-14 Completed Date: 2008-07-07 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 156-63 Citation Subset: IM |
Affiliation:
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Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Endopeptidases / metabolism Humans Ubiquitination / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DP2 OD003088-01/OD/NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.4.-/Endopeptidases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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