| Reverse cholesterol transport in the rat following a short-term intravenous infusion of fat emulsion. | |
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MedLine Citation:
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PMID: 8878245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect on cholesterol transport of an intravenous infusion of a fat emulsion (10%) Intralipid or 10% Lipovenös) in vivo was investigated in the rat. Intralipid (1.85 ml/hr/kg body weight in rts for 3 hr) caused a reduction (P < 0.05) in free cholesterol in the aorta (by 25%), in plasma high-density lipoproteins (64%) and in erythrocytes (11%) with a concomitant enrichment of liver free cholesterol (16%), suggesting an enhanced reverse cholesterol transport in this species. Lipovenös under the same conditions gave similar results. Our data support our previous in vivo study in man indicating that infusion of a fat emulsion is able even to remove cholesterol from the arterial wall and thereby possibly be considered as an antiatherosclerotic agent. |
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Authors:
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W Q Wang; X D Wang; Z W Sun; P Hanson; A Gustafson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology & toxicology Volume: 79 ISSN: 0901-9928 ISO Abbreviation: Pharmacol. Toxicol. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-01-13 Completed Date: 1997-01-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8702180 Medline TA: Pharmacol Toxicol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 49-54 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University Hospital, Lund, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / drug effects, metabolism Cholesterol / blood*, metabolism Erythrocytes / drug effects, metabolism Fat Emulsions, Intravenous / administration & dosage, pharmacology* Infusions, Intravenous Lipoproteins, HDL / blood, metabolism Lipoproteins, VLDL / blood, metabolism Liver / blood supply, drug effects, metabolism Male Parenteral Nutrition Rats Rats, Sprague-Dawley Triglycerides / blood, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 0/Lipoproteins, HDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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