Document Detail

Reverse cholesterol transport in the rat following a short-term intravenous infusion of fat emulsion.
MedLine Citation:
PMID:  8878245     Owner:  NLM     Status:  MEDLINE    
The effect on cholesterol transport of an intravenous infusion of a fat emulsion (10%) Intralipid or 10% Lipovenös) in vivo was investigated in the rat. Intralipid (1.85 ml/hr/kg body weight in rts for 3 hr) caused a reduction (P < 0.05) in free cholesterol in the aorta (by 25%), in plasma high-density lipoproteins (64%) and in erythrocytes (11%) with a concomitant enrichment of liver free cholesterol (16%), suggesting an enhanced reverse cholesterol transport in this species. Lipovenös under the same conditions gave similar results. Our data support our previous in vivo study in man indicating that infusion of a fat emulsion is able even to remove cholesterol from the arterial wall and thereby possibly be considered as an antiatherosclerotic agent.
W Q Wang; X D Wang; Z W Sun; P Hanson; A Gustafson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  79     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-01-13     Completed Date:  1997-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
Department of Internal Medicine, University Hospital, Lund, Sweden.
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MeSH Terms
Aorta / drug effects,  metabolism
Cholesterol / blood*,  metabolism
Erythrocytes / drug effects,  metabolism
Fat Emulsions, Intravenous / administration & dosage,  pharmacology*
Infusions, Intravenous
Lipoproteins, HDL / blood,  metabolism
Lipoproteins, VLDL / blood,  metabolism
Liver / blood supply,  drug effects,  metabolism
Parenteral Nutrition
Rats, Sprague-Dawley
Triglycerides / blood,  metabolism
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Lipoproteins, HDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 57-88-5/Cholesterol

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