Document Detail

Reverse cardiac remodeling enabled by mechanical unloading of the left ventricle.
MedLine Citation:
PMID:  20559975     Owner:  NLM     Status:  MEDLINE    
Cardiac remodeling is a characteristic and basic component of heart failure progression and is associated with a poor prognosis. Attenuating or reversing remodeling is an accepted goal of heart failure therapy. Cardiac mechanical support with left ventricular assist devices, in addition to its established role as "bridge to transplantation" or "destination therapy" in patients not eligible for cardiac transplantation, offers the potential for significant and sustained myocardial recovery through reverse remodeling. This review discusses the emerging role of left ventricular assist devices as a "bridge to recovery". Clinical and basic aspects of cardiac remodeling and cardiac reverse remodeling enabled by mechanical unloading, potential candidates for this modality of treatment as well as unresolved issues regarding the use of mechanical circulatory support as a bridge to recovery are discussed.
Konstantinos G Malliaras; John V Terrovitis; Stavros G Drakos; John N Nanas
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-09-30
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  2     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-25     Citation Subset:  IM    
Third Cardiology Department, University of Athens, Athens, Greece.
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MeSH Terms
Disease Progression
Heart Failure / physiopathology,  surgery,  therapy*
Heart Transplantation
Heart-Assist Devices* / adverse effects
Middle Aged
Patient Selection
Recovery of Function
Risk Assessment
Time Factors
Treatment Outcome
Ventricular Function, Left*
Ventricular Remodeling*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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