Document Detail

Reverse atrial electrical remodelling induced by continuous positive airway pressure in patients with severe obstructive sleep apnoea.
MedLine Citation:
PMID:  23179919     Owner:  NLM     Status:  Publisher    
BACKGROUND: Obstructive sleep apnoea (OSA) is associated with cardiovascular morbidity and mortality, including atrial arrhythmias. Continuous positive airway pressure (CPAP) is the gold standard treatment for OSA; its impact on atrial electrical remodelling has not been fully investigated. Signal-averaged p-wave (SAPW) duration is an accepted marker for atrial electrical remodelling. OBJECTIVE: The objective of this study is to determine whether CPAP induces reverse atrial electrical remodelling in patients with severe OSA. METHODS: Consecutive patients attending the Sleep Disorder Clinic at Kingston General Hospital underwent full polysomnography. OSA-negative controls and severe OSA were defined as apnoea-hypopnea index (AHI) < 5 events/hour and AHI ≥ 30 events/hour, respectively. SAPW duration was determined at baseline and after 4-6 weeks of CPAP in severe OSA patients or without intervention controls. RESULTS: Nineteen severe OSA patients and 10 controls were included in the analysis. Mean AHI and minimum oxygen saturation were 41.4 ± 10.1 events/hour and 80.5 ± 6.5 % in severe OSA patients and 2.8 ± 1.2 events/hour and 91.4 ± 2.1 % in controls. At baseline, severe OSA patients had a greater SAPW duration than controls (131.9 ± 10.4 vs 122.8 ± 10.5 ms; p = 0.02). After CPAP, there was a significant reduction of SAPW duration in severe OSA patients (131.9 ± 10.4 to 126.2 ± 8.8 ms; p < 0.001), while SAPW duration did not change after 4-6 weeks in controls. CONCLUSION: CPAP induced reverse atrial electrical remodelling in patients with severe OSA as represented by a significant reduction in SAPW duration.
Adrian Baranchuk; Helen Pang; Geoffrey E J Seaborn; Payam Yazdan-Ashoori; Damian P Redfearn; Christopher S Simpson; Kevin A Michael; Michael Fitzpatrick
Related Documents :
7136499 - Cerebrospinal fluid protein findings in cervical syndromes classified by myelography, a...
2413419 - Neuropathologic lesions and csf morphine concentrations during chronic continuous intra...
67039 - Multiple sclerosis: a clinico-biological study of 100 cases in spain.
23249869 - Role of new drugs for management of atrial fibrillation.
23563619 - Right atrial tachycardias related to regions of low-voltage myocardium in patients with...
6704799 - Fulminating haemophilus influenzae b meningitis.
17456869 - Determining contrast medium dose and rate on basis of lean body weight: does this strat...
10429719 - Lymphocytic interstitial pneumonia: thin-section ct findings in 22 patients.
9355899 - Arrhythmogenic marker for the sudden unexplained death syndrome in thai men.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-21
Journal Detail:
Title:  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     Volume:  -     ISSN:  1572-8595     ISO Abbreviation:  J Interv Card Electrophysiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708966     Medline TA:  J Interv Card Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cardiology Division, Kingston General Hospital, Queen's University, Kingston, ON, Canada,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparative distribution of complex fractionated atrial electrograms, high dominant frequency (HDF) ...
Next Document:  Clinical evaluation of a new technique to monitor return electrode skin temperature during radiofreq...