| Reversal of vasopressin-induced coronary vasoconstriction by a PGE1 analogue (ONO 1206) in primates. | |
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MedLine Citation:
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PMID: 6955802 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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17 (S)methyl-omega-homo trans delta 2 PGE1 (ONO 1206) an analogue of PGE1 was studied on vasopressin-induced ECG changes in four male monkeys and three female baboons. Bolus intravenous doses of vasopressin (0.8 I.U. to 1.0 I.U./kg) produced flattening of the T wave (2 monkeys) elevation of ST segment (1 baboon and 1 monkey) and inversion of T wave (1 baboon). Inverted T waves were also present in one baboon and one monkey prior to any drug administration. In four out of seven animals, boLus intravenous doses (5 to 15 micrograms/kg) of ONO 1206 reversed the ECG changes produced by vasopressin and in one animal ONO 1206 reversed the existing inverted T wave. These findings indicate that vasopressin is a suitable agent for the induction of coronary vasoconstriction in primates and that ONO 1206 is able to reverse this effect. |
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Authors:
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S R Kottegoda; P G Adaikan; S M Karim |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and medicine Volume: 8 ISSN: 0262-1746 ISO Abbreviation: Prostaglandins Leukot Med Publication Date: 1982 Apr |
Date Detail:
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Created Date: 1982-10-21 Completed Date: 1982-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206868 Medline TA: Prostaglandins Leukot Med Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 343-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alprostadil*
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analogs & derivatives* Animals Blood Pressure / drug effects Coronary Circulation / drug effects* Electrocardiography Female Macaca mulatta Male Papio Prostaglandins E, Synthetic / pharmacology* Vasoconstriction / drug effects* Vasodilator Agents / pharmacology* Vasopressins / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E, Synthetic; 0/Vasodilator Agents; 11000-17-2/Vasopressins; 74397-12-9/ONO 1206; 745-65-3/Alprostadil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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