| Reversal of the vasoconstrictor step of hyperacute xenogeneic rejection of the liver by endothelin antagonists. | |
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MedLine Citation:
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PMID: 10807679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of endothelin in the initial vasoconstrictor step of hyperacute xenogeneic rejection was investigated. Isolated rat livers were perfused in recirculation. Perfusion with human sera provided an ex vivo model of hyperacute rejection in a discordant combination. Perfusion of 10% xenogeneic serum induced a marked (70%) and sustained reduction of the liver flow and induced the release of endothelin into the perfusion medium. In contrast, perfusion of 10% allogeneic serum or of 10% decomplemented human serum induced a weak (25%) and transient reduction of the liver flow and induced the release of minimal amounts of endothelin. The simultaneous administration of BQ 123 and BQ 788, the respective antagonists of ET(A) and ET(B) endothelin receptors, or that of bosentan, a mixed ET(A)/ET(B) antagonist, antagonized the vasoconstrictor effect of 10% xenogeneic human serum, as well as that of 10(-9) M endothelin-1. The vasoconstrictor effects of xenogeneic serum on liver circulation are, at least partly, mediated through the release of endothelin by the graft. |
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Authors:
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B Zhang; L Wen; A Gomola; P P Massault; B Cherruau; D Houssin; B Weill; Y Calmus |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of pharmacology Volume: 130 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-08-10 Completed Date: 2000-08-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 402-8 Citation Subset: IM |
Affiliation:
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Laboratoire de Biologie Cellulaire, Faculté de Médecine Cochin-Port Royal, Université Paris V, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Endothelins / metabolism Graft Rejection / metabolism*, physiopathology Hemodynamics / drug effects Humans Immunohistochemistry Liver / drug effects*, metabolism, physiology Liver Transplantation* Male Perfusion Rats Rats, Sprague-Dawley Receptors, Endothelin / antagonists & inhibitors*, metabolism Vasoconstrictor Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Endothelins; 0/Receptors, Endothelin; 0/Vasoconstrictor Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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