Document Detail


Reversal of renovascular hypertension: role of the renal medulla.
MedLine Citation:
PMID:  3319107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fall in blood pressure, which occurs when renovascular hypertension is corrected surgically, offers a means of elucidating the factors responsible for blood pressure control. When Goldblatt two-kidney, one-clip hypertension in the rat is reversed by unclipping the renal artery, or by removal of the ischaemic kidney, restoration of normal blood pressure is due to a fall in peripheral resistance. This is associated with sodium retention and cannot be modified by inhibition of the renin-angiotensin system. The fall is, however, partially inhibited by chemical removal of the renal medulla by means of 2-bromo-ethylamine hydrobromide. When normal rats are chemically medullectomized, moderate hypertension is produced, which cannot be attributed to the renin-angiotensin system or sodium retention. It is concluded that a renomedullary vasodepressor system is ablated by chemical medullectomy: further, this system plays a role in the surgical correction of Goldblatt hypertension.
Authors:
J D Swales; R F Bing; M E Edmunds; G I Russell; H Thurston
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  65     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1988-02-11     Completed Date:  1988-02-11     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1566-71     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Leicester, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Heart Rate
Hypertension, Renovascular / physiopathology*,  therapy
Kidney Medulla / physiopathology*
Nephrectomy
Rats
Renal Circulation
Renin / blood
Vascular Resistance
Chemical
Reg. No./Substance:
EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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