Document Detail

Reversal of the relation between respiratory drive and airway tone in cats.
MedLine Citation:
PMID:  3175355     Owner:  NLM     Status:  MEDLINE    
To examine the relationship between respiratory drive and airway tone in the exercise pressor reflex in the cat, we recorded tension in a tracheal segment and activity in the phrenic nerve, before and after injecting capsaicin in various doses (0.3-20 micrograms/kg) into the femoral artery. Injection of all doses of capsaicin relaxed the tracheal segment. However, high doses of capsaicin evoked neural apnea followed by increased phrenic nerve activity whereas low doses evoked only increased phrenic nerve activity. All responses were abolished by cutting hindleg nerves. We were certain that relaxation was due to decreases of parasympathetic bronchoconstrictor activity and not to increases in activity of other inhibitory pathways, because we found no change in capsaicin-evoked relaxation after beta-adrenergic blockade with propranolol and no capsaicin-evoked relaxation after muscarinic blockade with atropine and restoration of tone with 5-hydroxytryptamine. These results provide good evidence that injecting capsaicin into the femoral artery reverses the direct relation between respiratory drive and airway tone and does so by decreasing parasympathetic bronchoconstrictor activity.
D G Baker; H Don
Related Documents :
3297055 - A disbalance between beta-adrenergic and muscarinic responses caused by hydrogen peroxi...
12099765 - Water aerosols and cough.
2980295 - Regional differences in the reactivity of guinea-pig airways.
16641215 - Bronchial muscle peristaltic activity in the fetal rat.
18572055 - Peripheral field loss: something old, something new.
10862115 - Immunohistochemical myofiber typing and high-resolution myofibrillar lesion detection i...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  73     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-10-31     Completed Date:  1988-10-31     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  21-30     Citation Subset:  IM    
Department of Anesthesia, University of California, San Francisco 94143.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Atropine / pharmacology
Blood Pressure / drug effects
Capsaicin / administration & dosage,  pharmacology*
Femoral Artery
Muscle Contraction / drug effects
Muscle Relaxation / drug effects
Muscle, Smooth / drug effects,  physiology
Phrenic Nerve / physiology*
Propranolol / pharmacology
Respiration* / drug effects
Trachea / innervation,  physiology*
Grant Support
Reg. No./Substance:
404-86-4/Capsaicin; 51-55-8/Atropine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Frequency dependence of dead space during high-frequency ventilation in rhesus monkeys.
Next Document:  Vagal influences on respiratory mechanics, pressures, and control in rats.