Document Detail

Reversal of postburn immunosuppression by the administration of vitamin A.
MedLine Citation:
PMID:  6235614     Owner:  NLM     Status:  MEDLINE    
The effect of high doses of vitamin A was evaluated on the suppression of cellular immunity after a 30% body surface area experimental scald burn in a mouse model. Male CBA/J mice were treated postburn with daily intraperitoneal injections of either 3000 IU of vitamin A or an equal volume of 0.9N saline. Similar groups of unburned mice were also studied as controls. At the seventh postburn day, one-way mixed lymphocyte reactions were tested for each group with whole spleen cells of CBA/J mice used as responders and mitomycin C-treated whole spleen cells of C57 BL/6 mice used as stimulators. When results were expressed as mean percentage of the values of control animals, no significant difference was observed between the saline-injected unburned control group (taken as 100%) and the vitamin A-treated unburned control groups (89%). The burned animals treated with saline showed suppression to 21% of the control values. However, the burned animals treated postburn with vitamin A improved the response rate dramatically to 52% of control values. This improvement over the untreated burned animals was significant in all experiments performed (p less than 0.02). This study suggests that vitamin A may be an effective agent in the reversal of cellular immunosuppression after burns.
S Fusi; T S Kupper; D R Green; S Ariyan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgery     Volume:  96     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-08-29     Completed Date:  1984-08-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  330-5     Citation Subset:  AIM; IM    
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MeSH Terms
Burns / drug therapy*,  immunology
Cell Division / drug effects
Dose-Response Relationship, Drug
Immune Tolerance / drug effects*
Lymphocyte Culture Test, Mixed
Lymphocytes / drug effects
Mice, Inbred C57BL
Mice, Inbred CBA
Vitamin A / therapeutic use*
Reg. No./Substance:
11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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