Document Detail

Reversal of obesity-related hypoadiponectinemia by lifestyle intervention: a controlled, randomized study in obese adolescents.
MedLine Citation:
PMID:  16131584     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Hypoadiponectinemia and chronic subclinical inflammation in adults are associated with the development of diabetes and cardiovascular disease. The potential relationship between adiponectin and inflammation and its modulation by lifestyle intervention in the pediatric obese population remain unclear.
OBJECTIVES: The objectives were to investigate in adolescents 1) the relationship between adiponectin and obesity-related inflammatory factors, C-reactive protein, and IL-6; and 2) the effect of a lifestyle intervention on adiponectin and whether these effects are related to changes in inflammatory factors.
RESEARCH METHODS AND PROCEDURES: Twenty-one obese and age-matched lean adolescents (age, 14-18 yr; Tanner stage, > or =IV) were studied cross-sectionally. Fifteen obese adolescents also underwent a randomized, controlled physical activity-behavior-diet-based lifestyle intervention for 3 months. Associations among adiponectin, fat mass, insulin resistance, and inflammatory factors at baseline as well as after the intervention were assessed.
RESULTS: Plasma adiponectin concentration was lower (P < 0.001) in the obese vs. age-matched lean adolescents. Significant inverse relationships were observed between adiponectin and inflammatory factors, insulinemia, insulin resistance, and fat mass. Intervention produced a 34% increase in adiponectin concentration (P = 0.0004) despite negligible weight loss but with reductions in fat mass, hyperinsulinemia, insulin resistance, and inflammatory factors (all P < 0.01).
CONCLUSIONS: The data suggest that in adolescents, obesity-related hypoadiponectinemia is associated with subclinical inflammation, and a short-term lifestyle intervention augments adiponectin concentrations. These effects appear to be related to reductions in fat mass and inflammatory factors. Based on our current understanding of adiponectin physiology, reversal of hypoadiponectinemia in obese adolescents may protect against risks for cardiovascular disease and diabetes.
Prabhakaran Balagopal; Donald George; Hossein Yarandi; Vicky Funanage; Edward Bayne
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2005-08-30
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  90     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-08     Completed Date:  2005-12-02     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6192-7     Citation Subset:  AIM; IM    
Nemours Children's Clinic, 807 Children's Way, Jacksonville, Florida 32207, USA.
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MeSH Terms
Adiponectin / blood
Adipose Tissue / metabolism
Body Mass Index
C-Reactive Protein / analysis
Cross-Sectional Studies
Inflammation / etiology,  prevention & control*
Insulin Resistance
Interleukin-6 / blood
Life Style*
Obesity / blood*,  complications
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Interleukin-6; 9007-41-4/C-Reactive Protein

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