Document Detail


Reversal of nephrotic syndrome due to AA amyloidosis in psoriatic patients on long-term colchicine treatment. Case report and review of the literature.
MedLine Citation:
PMID:  10450037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A case of nephrotic syndrome due to AA amyloidosis in a young woman suffering from erythrodermic psoriasis and psoriatic arthropathy is reported. The nephrotic syndrome regressed completely during long-term (57 months) colchicine treatment. There are 39 case reports in the literature of psoriasis associated with amyloidosis. More than 85% of these patients had concomitant arthropathy. This suggests that arthritis may be an important factor in the appearance of amyloidosis. 59% of psoriatics with amyloidosis had renal failure and 56% of them died shortly after diagnosis of amyloidosis. These observations support the view that amyloidosis associated with psoriasis is an aggressive disease that may be fatal. However, the clinical course of our patient suggests that renal amyloidosis associated with psoriasis may be successfully treated by colchicine.
Authors:
A Kagan; M Husza'r; A Frumkin; J Rapoport
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Nephron     Volume:  82     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1999  
Date Detail:
Created Date:  1999-10-07     Completed Date:  1999-10-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  348-53     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Hypertension, Kaplan Medical Center, Rehovot, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amyloidosis / complications,  drug therapy*,  pathology
Arthritis, Psoriatic / complications,  drug therapy*,  pathology
Colchicine / therapeutic use*
Dermatitis, Exfoliative / complications,  drug therapy,  pathology
Female
Humans
Nephrotic Syndrome / drug therapy*,  etiology,  pathology
Time
Treatment Outcome
Chemical
Reg. No./Substance:
64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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