Document Detail

Reversal of narcotic depression in the neonate by nalozone.
MedLine Citation:
PMID:  990784     Owner:  NLM     Status:  MEDLINE    
Naloxone 40 mug was administered intravenously one minute after birth to 20 out of 44 neonates whose mother had been given pethidine in labour. These neonates were compared with 20 others whose mothers had had only lumbar epidural block. Alveolar PCO2, alveolar ventilation, and ventilatory rate were measured 10 and 30 minutes after birth. The untreated neonates of mothers who had had pethidine showed significant ventilatory depression compared with infants in the epidural and naloxone-treated groups. The naloxone-treated neonates were comparable with the epidural group, although the effects of naloxone were diminishing at 30 minutes. Naloxone is an effective narcotic antagonist which should be considered to be the drug of choice for treating narcotic depression in the neonate.
J M Evans; M I Hogg; M Rosen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British medical journal     Volume:  2     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-01-25     Completed Date:  1977-01-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1098-100     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Obstetrical / adverse effects*
Apgar Score
Carbon Dioxide / analysis
Infant, Newborn
Infant, Newborn, Diseases / drug therapy*
Maternal-Fetal Exchange
Meperidine / adverse effects*
Naloxone / therapeutic use*
Pulmonary Alveoli / analysis
Respiratory Insufficiency / chemically induced*,  drug therapy
Time Factors
Reg. No./Substance:
124-38-9/Carbon Dioxide; 465-65-6/Naloxone; 57-42-1/Meperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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