| Reversal of narcotic depression in the neonate by nalozone. | |
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MedLine Citation:
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PMID: 990784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Naloxone 40 mug was administered intravenously one minute after birth to 20 out of 44 neonates whose mother had been given pethidine in labour. These neonates were compared with 20 others whose mothers had had only lumbar epidural block. Alveolar PCO2, alveolar ventilation, and ventilatory rate were measured 10 and 30 minutes after birth. The untreated neonates of mothers who had had pethidine showed significant ventilatory depression compared with infants in the epidural and naloxone-treated groups. The naloxone-treated neonates were comparable with the epidural group, although the effects of naloxone were diminishing at 30 minutes. Naloxone is an effective narcotic antagonist which should be considered to be the drug of choice for treating narcotic depression in the neonate. |
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Authors:
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J M Evans; M I Hogg; M Rosen |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British medical journal Volume: 2 ISSN: 0007-1447 ISO Abbreviation: Br Med J Publication Date: 1976 Nov |
Date Detail:
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Created Date: 1977-01-25 Completed Date: 1977-01-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372673 Medline TA: Br Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1098-100 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Obstetrical
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adverse effects* Apgar Score Carbon Dioxide / analysis Female Humans Infant, Newborn Infant, Newborn, Diseases / drug therapy* Maternal-Fetal Exchange Meperidine / adverse effects* Naloxone / therapeutic use* Pregnancy Pulmonary Alveoli / analysis Respiratory Insufficiency / chemically induced*, drug therapy Time Factors |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 465-65-6/Naloxone; 57-42-1/Meperidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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