Document Detail


Reversal of the limited proteolysis of MP26 during the reversal and prevention of the galactose cataract in rat lenses.
MedLine Citation:
PMID:  2189687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reversal and prevention of the galactose-induced cataract in rats were employed to study their effects on the acceleration of the limited proteolysis of MP26 into MP23-24 previously observed in cataractous lenses of galactose-fed animals. Lenses of rats on a cataract reversal-diet demonstrated the reversal of MP23-24 and MP26 levels to control levels in the clearing cortical areas but not in remaining cataractous nuclear areas. Acceleration of the limited proteolysis of MP26 was observed in the nucleus but not the cortex in the clear lenses of animals on a cataract prevention-diet. The results demonstrated that the limited proteolysis of MP26 may form part of a gradual aging process that although not directly (causally) related to cataractogenesis may at least be accelerated by cataractogenic agents or conditions.
Authors:
J Alcala; N Unakar; M Katar; J Tsui
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Current eye research     Volume:  9     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-07-11     Completed Date:  1990-07-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  225-32     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Aquaporins
Cataract / chemically induced,  metabolism*,  prevention & control
Diet
Electrophoresis, Polyacrylamide Gel
Eye Proteins / metabolism*
Female
Galactose / administration & dosage*
Lens Cortex, Crystalline / metabolism
Lens Nucleus, Crystalline / metabolism
Lens, Crystalline / metabolism*
Membrane Glycoproteins*
Peptide Hydrolases / metabolism
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
EY 01680/EY/NEI NIH HHS; EY 01855/EY/NEI NIH HHS; EY 04068/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Aquaporins; 0/Eye Proteins; 0/Membrane Glycoproteins; 0/aquaporin 0; 26566-61-0/Galactose; EC 3.4.-/Peptide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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