| Reversal of hepatoma cells resistance to anticancer drugs is correlated to cell proliferation kinetics, telomere length and telomerase activity. | |
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MedLine Citation:
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PMID: 16101139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Clinical and experimental observations indicate that resistance to anticancer drugs may be spontaneously reversible over time. MATERIALS AND METHODS: This work is a mathematical and statistical analysis of the relationship, during a 9-month experiment, between the resistance of repeatedly re-seeded hepatoma cells to methotrexate (MTX) or to cisplatin (cisP) and untreated cell proliferation, telomere length and telomerase activity. RESULTS: All variables showed complex oscillations, as previously published. In this work, cell proliferation was modelized by the logistic model, and the proliferation rates (a-values) together with their variations (va-values) were calculated. CONCLUSION: Significant correlations were discovered between cell resistance to treatments and a-values, va-values, telomere length and telomerase activities. These results open new insights into the handling of chemotherapy in the treatment of cancers. |
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Authors:
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Nguyen Phong Chau; Jean Deschatrette; Claire Wolfrom |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anticancer research Volume: 25 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 2005 Sep-Oct |
Date Detail:
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Created Date: 2005-08-16 Completed Date: 2005-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 3279-85 Citation Subset: IM |
Affiliation:
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Equipe Biomath-Biostat, Université Paris 7-Denis Diderot, 2 place Jussieu, 75251 Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / pharmacology* Cell Growth Processes / physiology Cisplatin / pharmacology* Drug Resistance, Neoplasm Liver Neoplasms, Experimental / drug therapy*, enzymology, genetics, pathology Logistic Models Methotrexate / pharmacology* Predictive Value of Tests Rats Telomerase / metabolism* Telomere / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 15663-27-1/Cisplatin; 59-05-2/Methotrexate; EC 2.7.7.49/Telomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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