| Reversal of heart failure remodeling with age. | |
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MedLine Citation:
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PMID: 12214168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since heart failure is a major cause of morbidity in the elderly, we studied the effect of up-titrated heart failure therapy in older vs. younger individuals on symptoms and left ventricular (LV) function over 1 year. Seventy-one patients with heart failure and an LV ejection fraction < or =35% were enrolled and were followed with echocardiography at baseline and at 1 year. Young patients were born in or after 1935 (n=48; 51.7+/-9.1 years); middle-aged were born between 1925-1934 (n=14; 69.7+/-2.8 years); and older patients in or prior to 1924 (n=9; 80.5+/-3.3 years). Baseline LV ejection fraction was 18%+/-7%, LV end-diastolic diameter 6.9+/-0.9 cm, and New York Heart Association class was 2.6+/-1.0, equivalent for all groups. On medical therapy, at 12 months, LV ejection fraction improved only for the young and middle-aged (36%+/-14% and 37%+/-17%; p=0.002), but not for the older patients (22%+/-7%; p=NS). Reductions in LV end-diastolic diameter and mitral regurgitation were significant only for the young. However, New York Heart Association status improved similarly for all groups (1.6+/-0.8; p<0.001), as did heart failure hospitalizations (p<0.0001). Although all groups tolerated intensified heart failure therapy, only the young and middle-aged improved LV remodeling. However, older patients experienced equivalent significant improvements in heart failure symptoms and hospitalizations. |
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Authors:
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T Barry Levine; Arlene B Levine; Janet Bolenbaugh; Pamela R Green |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The American journal of geriatric cardiology Volume: 11 ISSN: 1076-7460 ISO Abbreviation: Am J Geriatr Cardiol Publication Date: 2002 Sep-Oct |
Date Detail:
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Created Date: 2002-09-05 Completed Date: 2002-11-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9215283 Medline TA: Am J Geriatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 299-304 Citation Subset: IM |
Copyright Information:
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Copyright 2002 CVRR, Inc. |
Affiliation:
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Michigan Institute for Heart Failure and Transplant Care, Botsford General Hospital, Farmington Hills, MI, USA. Blevine@WAAHS.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / physiology* Angiotensin-Converting Enzyme Inhibitors / administration & dosage*, therapeutic use* Dose-Response Relationship, Drug Echocardiography Female Heart Failure / drug therapy*, physiopathology*, ultrasonography Humans Male Middle Aged Prospective Studies Remission Induction Time Factors Ventricular Remodeling / drug effects*, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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