Document Detail

Reversal of fungitoxicity of 8-quinolinols and their copper (II) bischelates. I. Amino acids and related compounds.
MedLine Citation:
PMID:  1116048     Owner:  NLM     Status:  MEDLINE    
The effect of amino acids and related compounds on the toxicity of 8-quinolinols and their copper (II) bischelates to Aspergillus oryzae (ATCC 1011) Was studied. None of the compounds tested except the thiol-containing compounds, cysteine, cysteamine, glutathione, and N-acetylcysteine reversed the inhibitory action of 8-quinolinol but not that of 5-iodo-8-quinolinol or bis (8-quinolinolato) copper (II). It appears that the mechanism(s) of fungitoxicity of 8-quinolinol is different from that of 5-iodo-8-quinolinol or bis(8-quinolinolato) copper (II.).
H Gershon; R Parmegiani; J B Hauck
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Canadian journal of microbiology     Volume:  21     ISSN:  0008-4166     ISO Abbreviation:  Can. J. Microbiol.     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-06-12     Completed Date:  1975-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372707     Medline TA:  Can J Microbiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  409-11     Citation Subset:  IM    
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MeSH Terms
Acetylcysteine / pharmacology
Amino Acids / pharmacology*
Antifungal Agents*
Aspergillus / drug effects*,  growth & development
Copper / pharmacology*
Cysteamine / pharmacology
Cysteine / pharmacology
Drug Antagonism
Glutathione / pharmacology
Organometallic Compounds / pharmacology*
Quinolines / pharmacology*
Reg. No./Substance:
0/Amino Acids; 0/Antifungal Agents; 0/Organometallic Compounds; 0/Quinolines; 52-90-4/Cysteine; 60-23-1/Cysteamine; 616-91-1/Acetylcysteine; 70-18-8/Glutathione; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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