| Reversal of fundic atrophy after eradication of Helicobacter pylori. | |
| | |
MedLine Citation:
|
PMID: 9732919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: We sought to evaluate the effect of Helicobacter pylori eradication in patients with fundic atrophic gastritis. METHODS: Acid secretion, gastric emptying, and histology were evaluated in 20 patients with fundic atrophic gastritis and H. pylori infection. After investigation, 10 patients (Group 1) received an eradicating treatment and 10 (Group 2) did not receive any treatment. One year later, the baseline investigations were repeated. Subsequently, patients in Group 2 received the same treatment given to patients in Group 1 and were reevaluated 12 months later. A further follow-up was performed in both groups 36 months after the treatment. RESULTS: At 1-yr follow-up, all the patients in Group 1 were H. pylori negative whereas all the patients in Group 2 were still infected. In Group 1, there was a significant improvement of both fundic atrophy and acid secretion, compared with baseline (p < 0.01). In Group 2, no substantial modification of either histological or functional parameters was observed at the first follow-up; conversely, a significant (p < 0.01) improvement of fundic atrophy and acid secretion was detected in these patients 12 months after eradication of the bacterium. Histological pattern remained unchanged at 36 months of follow-up in both groups. Gastric emptying remained, on the average, unaffected by the treatment; however, three patients with delayed gastric emptying at entry had normal gastric emptying after eradication of H. pylori. CONCLUSIONS: Our data suggest that mucosal atrophy can be reduced or even reversed by the eradication of H. pylori, and this is associated with a recovery of gastric function. |
| | |
Authors:
|
A Tucci; L Poli; C Tosetti; G Biasco; W Grigioni; O Varoli; C Mazzoni; G F Paparo; V Stanghellini; G Caletti |
Related Documents
:
|
6691639 - Reminders to physicians from an introspective computer medical record. a two-year rando... 22057499 - Treatment of high grade cervical intraepithelial neoplasia by photodynamic therapy usin... 7311109 - Serological survey for sv5, measles and herpes simplex infections in newly-imported cyn... 9663839 - Four-day quadruple therapy as a routine treatment for helicobacter pylori infection. 7980309 - Randomized prospective intervention study of human cervical wart virus infection. 16497629 - Regression of primary low-grade mucosa-associated lymphoid tissue lymphoma of duodenum ... 11445479 - Phase ii trial of bicalutamide in patients with advanced prostate cancer in whom conven... 20494159 - Assessing pest control using changes in instantaneous rate of population increase: trea... 15272129 - Individual patient data meta-analysis of randomized controlled trials of community occu... |
Publication Detail:
|
Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: 93 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1998 Sep |
Date Detail:
|
Created Date: 1998-09-15 Completed Date: 1998-09-15 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1425-31 Citation Subset: IM |
Affiliation:
|
Institute of Medical Clinic & Gastroenterology, Department of Pathology, Hospital S. Orsola-Malpighi, University of Bologna, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amoxicillin
/
therapeutic use Anti-Bacterial Agents / therapeutic use Anti-Ulcer Agents / therapeutic use Atrophy / drug therapy, pathology Female Follow-Up Studies Gastric Acid / secretion Gastric Emptying Gastric Fundus / pathology Gastritis / drug therapy, pathology*, physiopathology* Helicobacter Infections / drug therapy*, pathology, physiopathology Helicobacter pylori* Humans Male Metronidazole / therapeutic use Middle Aged Organometallic Compounds / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Organometallic Compounds; 26787-78-0/Amoxicillin; 443-48-1/Metronidazole; 57644-54-9/bismuth tripotassium dicitrate |
| Comments/Corrections | |
Comment In:
|
Am J Gastroenterol. 1998 Sep;93(9):1407-8
[PMID:
9732916
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Nonsteroidal antiinflammatory drug use and gallstone disease prevalence: a case-control study.
Next Document: Clarithromycin-resistant Helicobacter pylori in patients with duodenal ulcer in the United States.