Document Detail

Reversal of fundic atrophy after eradication of Helicobacter pylori.
MedLine Citation:
PMID:  9732919     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We sought to evaluate the effect of Helicobacter pylori eradication in patients with fundic atrophic gastritis. METHODS: Acid secretion, gastric emptying, and histology were evaluated in 20 patients with fundic atrophic gastritis and H. pylori infection. After investigation, 10 patients (Group 1) received an eradicating treatment and 10 (Group 2) did not receive any treatment. One year later, the baseline investigations were repeated. Subsequently, patients in Group 2 received the same treatment given to patients in Group 1 and were reevaluated 12 months later. A further follow-up was performed in both groups 36 months after the treatment. RESULTS: At 1-yr follow-up, all the patients in Group 1 were H. pylori negative whereas all the patients in Group 2 were still infected. In Group 1, there was a significant improvement of both fundic atrophy and acid secretion, compared with baseline (p < 0.01). In Group 2, no substantial modification of either histological or functional parameters was observed at the first follow-up; conversely, a significant (p < 0.01) improvement of fundic atrophy and acid secretion was detected in these patients 12 months after eradication of the bacterium. Histological pattern remained unchanged at 36 months of follow-up in both groups. Gastric emptying remained, on the average, unaffected by the treatment; however, three patients with delayed gastric emptying at entry had normal gastric emptying after eradication of H. pylori. CONCLUSIONS: Our data suggest that mucosal atrophy can be reduced or even reversed by the eradication of H. pylori, and this is associated with a recovery of gastric function.
A Tucci; L Poli; C Tosetti; G Biasco; W Grigioni; O Varoli; C Mazzoni; G F Paparo; V Stanghellini; G Caletti
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  93     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-09-15     Completed Date:  1998-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1425-31     Citation Subset:  IM    
Institute of Medical Clinic & Gastroenterology, Department of Pathology, Hospital S. Orsola-Malpighi, University of Bologna, Italy.
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MeSH Terms
Amoxicillin / therapeutic use
Anti-Bacterial Agents / therapeutic use
Anti-Ulcer Agents / therapeutic use
Atrophy / drug therapy,  pathology
Follow-Up Studies
Gastric Acid / secretion
Gastric Emptying
Gastric Fundus / pathology
Gastritis / drug therapy,  pathology*,  physiopathology*
Helicobacter Infections / drug therapy*,  pathology,  physiopathology
Helicobacter pylori*
Metronidazole / therapeutic use
Middle Aged
Organometallic Compounds / therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Ulcer Agents; 0/Organometallic Compounds; 26787-78-0/Amoxicillin; 443-48-1/Metronidazole; 57644-54-9/bismuth tripotassium dicitrate
Comment In:
Am J Gastroenterol. 1998 Sep;93(9):1407-8   [PMID:  9732916 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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