Document Detail


Reversal of food restriction-induced inhibition of mouse skin tumor promotion by adrenalectomy.
MedLine Citation:
PMID:  1423856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Restricting the food intake of laboratory mice and rats markedly reduces the incidence of spontaneous and experimentally induced cancers. Using the two-stage skin tumorigenesis model in CD-1 mice, we report now that food restriction suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of epidermal [3H]thymidine incorporation as well as TPA promotion of skin papillomas, whereas adrenalectomy completely reverses the inhibition in [3H]thymidine incorporation and tumor development. These results suggest that the adrenal gland may play an important role in mediating the tumor inhibitory effect of food restriction.
Authors:
L L Pashko; A G Schwartz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Carcinogenesis     Volume:  13     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-27     Completed Date:  1992-11-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1925-8     Citation Subset:  IM    
Affiliation:
Feis Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / physiology,  surgery
Adrenalectomy*
Animals
Body Weight / drug effects,  physiology
Corticosterone / blood
DNA, Neoplasm / biosynthesis
Dehydroepiandrosterone / pharmacology
Female
Food
Mice
Mice, Inbred Strains
Papilloma / chemically induced,  diet therapy*
Skin Neoplasms / chemically induced,  diet therapy*,  etiology
Stimulation, Chemical
Tetradecanoylphorbol Acetate / pharmacology
Grant Support
ID/Acronym/Agency:
CA 12227/CA/NCI NIH HHS; CA 52500/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 16561-29-8/Tetradecanoylphorbol Acetate; 50-22-6/Corticosterone; 53-43-0/Dehydroepiandrosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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