Document Detail

Reversal of fentanyl induced spasm of the sphincter of Oddi.
MedLine Citation:
PMID:  6828978     Owner:  NLM     Status:  MEDLINE    
We believe it is advisable to avoid narcotics, if possible, in patients with known or suspected gallbladder disease. Occasionally, however, this will not be possible, and narcotic induced spasm of the sphincter of Oddi may require treatment. Except for the stated contraindications of glucagon administration, it seems to be based upon this study and other available data that glucagon is just as effective as naloxone in reversing spasm of the sphincter of Oddi and may be associated with fewer undesirable effects, such as reversal of analgesia and adverse hemodynamic changes. Anticholingergic drugs in man have proved to be of minimal or no benefit in this regard.
R L McCammon; R Stoelting; J A Madura
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  156     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  329-34     Citation Subset:  AIM; IM    
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MeSH Terms
Ampulla of Vater / drug effects*
Atropine / pharmacology
Fentanyl / adverse effects,  antagonists & inhibitors*
Glucagon / pharmacology
Manometry / instrumentation
Naloxone / pharmacology
Parasympatholytics / pharmacology*
Sodium Chloride / pharmacology
Spasm / chemically induced,  drug therapy*
Sphincter of Oddi / drug effects*
Reg. No./Substance:
0/Parasympatholytics; 437-38-7/Fentanyl; 465-65-6/Naloxone; 51-55-8/Atropine; 7647-14-5/Sodium Chloride; 9007-92-5/Glucagon

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