Document Detail

Reversal of clonidine toxicity by naloxone.
MedLine Citation:
PMID:  3752658     Owner:  NLM     Status:  MEDLINE    
Clonidine is a centrally acting antihypertensive agent used in the management of essential hypertension. Oral clonidine loading is now used frequently in the management of hypertensive urgencies (ie, increases in arterial pressure not associated with acute, life-threatening end-organ injury). We report the case of a patient with an acute inferior myocardial infarction associated with blunt chest trauma who developed an abrupt and unexplained increase in arterial pressure 24 hours after admission and who was treated with oral clonidine (0.5 mg in divided doses over two hours). Drug therapy was followed by prolonged (four hours) systemic arterial hypotension (mean arterial pressure less than 70 mm Hg). Four milligrams of naloxone in two divided doses was given. Each naloxone bolus was followed by a 15-mm-Hg increase in mean arterial pressure and a return to values that were normal for this patient. Naloxone may be of value in reversing clonidine toxicity when clonidine is given to treat an acute rise in arterial pressure.
J T Niemann; T Getzug; W Murphy
Related Documents :
23219628 - Oxford grading scale vs manometer for assessment of pelvic floor strength in nulliparou...
635588 - 3-methoxy-4-hydroxyphenylglycol in cerebrospinal fluid and vanillylmandelic acid in uri...
9740318 - Endomorphin 1 and 2, the endogenous mu-opioid agonists, produce biphasic changes in sys...
628 - Investigation into some imidazoline compounds, with respect to peripheral alpha-adrenoc...
7007608 - The relationship between peak inspiratory pressure and positive end expiratory pressure...
25000548 - Characterizing workers participating in a worksite wellness health screening program us...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  15     ISSN:  0196-0644     ISO Abbreviation:  Ann Emerg Med     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-10-22     Completed Date:  1986-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1229-31     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Accidents, Traffic
Clonidine / adverse effects,  antagonists & inhibitors*
Hypertension / drug therapy*
Hypotension / chemically induced,  drug therapy*
Myocardial Infarction / etiology
Naloxone / pharmacology*
Wounds, Nonpenetrating / complications
Reg. No./Substance:
4205-90-7/Clonidine; 465-65-6/Naloxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ciguatera poisoning: a report of three cases.
Next Document:  Penetrating abdominal wounds in pregnancy.