Document Detail

Reversal of cardiac hypertrophy by medical treatment.
MedLine Citation:
PMID:  3158269     Owner:  NLM     Status:  MEDLINE    
Reversal of left ventricular hypertrophy in hypertensive patients has been proven to follow effective blood pressure control by some antihypertensive drugs. This reversal does not depend solely on the degree of pressure reduction but is also modulated by other factors including, among others, stability of blood pressure control, degree of cardioadrenergic stimulation, and individual variations due to genetic background and possible age. Regression of left ventricular hypertrophy is most likely to occur when the reduction in arterial pressure and peripheral resistance can be maintained without induced reflex cardiac stimulation. Left ventricular performance at rest was not depressed by the reduction in cardiac mass but remained normal both in absolute terms and in relation to changes in LV end-systolic stress.
R C Tarazi; F M Fouad
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of medicine     Volume:  36     ISSN:  0066-4219     ISO Abbreviation:  Annu. Rev. Med.     Publication Date:  1985  
Date Detail:
Created Date:  1985-06-17     Completed Date:  1985-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985151R     Medline TA:  Annu Rev Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  407-14     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Cardiomegaly / drug therapy*,  physiopathology
Coronary Circulation
Hypertension / complications*,  pathology,  physiopathology
Myocardial Contraction
Myocardium / pathology
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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