Document Detail

Reversal by bile acid on the inhibition of alpha-tocopherol absorption by retinoic acid.
MedLine Citation:
PMID:  7057276     Owner:  NLM     Status:  MEDLINE    
This study explores several possible mechanisms by which dietary retinoic acid may cause the previously described reduced intestinal absorption of alpha-tocopherol. Measurement of fecal excretion of rats showed that dietary retinoic acid caused twice as much alpha-tocopherol to be excreted as when retinol was the source of vitamin A. Excretion was the same for free and esterified alpha-tocopherol, thus, the retinoic acid effect originally observed was not due to impaired hydrolysis of the ester. There was no effect of retinoic acid on triglyceride absorption. Collection and analysis of bile from rats fed either form of vitamin A showed no difference in bile volume or bile acid composition. The addition of 0.2% taurocholic acid to the diet, however, reversed the effect of retinoic acid on tocopherol absorption. In vitro studies of mixed micelles containing 3H-alpha-tocopherol and retinoic acid or retinol showed no difference in size due to the form of vitamin A in the micelles.
J G Bieri; T J Tolliver
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  112     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-3     Citation Subset:  IM    
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MeSH Terms
Bile / analysis
Bile Acids and Salts / pharmacology*
Feces / analysis
Intestinal Absorption / drug effects*
Taurocholic Acid / pharmacology
Tretinoin / pharmacology*
Vitamin A / pharmacology
Vitamin E / metabolism*
Reg. No./Substance:
0/Bile Acids and Salts; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 302-79-4/Tretinoin; 81-24-3/Taurocholic Acid

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