Document Detail


Reversal by bile acid on the inhibition of alpha-tocopherol absorption by retinoic acid.
MedLine Citation:
PMID:  7057276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study explores several possible mechanisms by which dietary retinoic acid may cause the previously described reduced intestinal absorption of alpha-tocopherol. Measurement of fecal excretion of rats showed that dietary retinoic acid caused twice as much alpha-tocopherol to be excreted as when retinol was the source of vitamin A. Excretion was the same for free and esterified alpha-tocopherol, thus, the retinoic acid effect originally observed was not due to impaired hydrolysis of the ester. There was no effect of retinoic acid on triglyceride absorption. Collection and analysis of bile from rats fed either form of vitamin A showed no difference in bile volume or bile acid composition. The addition of 0.2% taurocholic acid to the diet, however, reversed the effect of retinoic acid on tocopherol absorption. In vitro studies of mixed micelles containing 3H-alpha-tocopherol and retinoic acid or retinol showed no difference in size due to the form of vitamin A in the micelles.
Authors:
J G Bieri; T J Tolliver
Related Documents :
6824336 - The biological activity of rat intestinal retinoic acid metabolites in the vaginal smea...
11215876 - Pseudotumor cerebri caused by all-trans-retinoic acid: a case report.
10645966 - Retinoic acid inhibition of cardiac mesenchyme formation in vitro correlates with chang...
10381496 - Complete remission of t(11;17) positive acute promyelocytic leukemia induced by all-tra...
16665846 - Inhibition of acetyl-coa carboxylase activity by haloxyfop and tralkoxydim.
19166726 - Comparison of different amino acid derivatives and analysis of rat brain microdialysate...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  112     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  401-3     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bile / analysis
Bile Acids and Salts / pharmacology*
Feces / analysis
Intestinal Absorption / drug effects*
Male
Rats
Taurocholic Acid / pharmacology
Tretinoin / pharmacology*
Vitamin A / pharmacology
Vitamin E / metabolism*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 302-79-4/Tretinoin; 81-24-3/Taurocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Protein synthesis rate in liver and muscle of rats following four days of overfeeding.
Next Document:  How does one interpret a marginally abnormal serum chemistry test?