Document Detail

Reversal by NS-7, a neuroprotective compound, of the decrease in transcription factor CREB mRNA expression in rat brain after permanent middle cerebral artery occlusion.
MedLine Citation:
PMID:  11403938     Owner:  NLM     Status:  MEDLINE    
The effect of a neuroprotective agent NS-7 on changes in mRNA expressions for cyclic AMP responsive element binding protein (CREB) and several neurotrophins was examined in the rat cerebral cortex after permanent middle cerebral artery occlusion (MCAO). Significant reduction in mRNA expressions for CREB was observed at 24h after MCAO. NS-7 (0.5mg/kg), when injected at 6h after MCAO, significantly reversed the decreased expression for CREB mRNA. In addition, the mRNA expression for basic fibroblast growth factor (bFGF) was also significantly enhanced by NS-7 in MCA-occluded but not in sham-operated rats. On the other hand, the mRNAs for interluekin-6 and inducible-type nitric oxide synthase were markedly induced in the cerebral cortex of MCA-occluded rats, which was not significantly reversed by NS-7. Therefore, it is suggested that the reversal of decrease in CREB mRNA and concomitant increase in mRNA expression for bFGF may contribute to the neuroprotective action of NS-7.
M Hirouchi; Y Itoh; Y Aoki; M Oka; Y Ukai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  305     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-08-02     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
Research Laboratories, Nippon Shinyaku Co. Ltd., Nishiohji Hachijo Minami-ku, 601-8550, Kyoto, Japan.
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MeSH Terms
Arterial Occlusive Diseases / metabolism*
Brain / metabolism*
Brain-Derived Neurotrophic Factor / genetics
Cerebral Arteries*
Cyclic AMP Response Element-Binding Protein / genetics*
Fibroblast Growth Factor 2 / genetics
Neuroprotective Agents / pharmacology*
Proto-Oncogene Proteins c-bcl-2 / metabolism
Pyrimidines / pharmacology*
RNA, Messenger / metabolism*
Rats, Sprague-Dawley
Reg. No./Substance:
0/4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride; 0/Brain-Derived Neurotrophic Factor; 0/Cyclic AMP Response Element-Binding Protein; 0/Neuroprotective Agents; 0/Proto-Oncogene Proteins c-bcl-2; 0/Pyrimidines; 0/RNA, Messenger; 103107-01-3/Fibroblast Growth Factor 2

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