Document Detail

Reversal of the arrhythmogenic effects of long-term saturated fatty acid intake by dietary n-3 and n-6 polyunsaturated fatty acids.
MedLine Citation:
PMID:  2296929     Owner:  NLM     Status:  MEDLINE    
This study investigated whether the adverse influences of dietary saturated animal fatty acids (SF) on vulnerability to cardiac arrhythmias in rats could be modified by crossover in maturity to diets rich in polyunsaturated fatty acids (PUFAs). The arrhythmia model was coronary artery occlusion and reperfusion under anesthesia. Animals were fed commercial stock diet (4% fat wt:wt) supplemented (12% wt:wt) with fat (final diets, 35% energy as fat). Of rats fed the SF diet for 9 and 18 mo, ventricular fibrillation (VF) occurred in 71% during occlusion and in 86% on reperfusion. Mortality from VF was 0% after 9 mo on the SF diet but 67% after 18 mo. Dietary crossover to n-3 (tuna-fish oil) or n-6 (sunflower-seed oil) PUFA-supplemented diets at 9 mo reduced arrhythmias (VF incidence less than 30% in occlusion and reperfusion) and mortality (0%). The n-3 PUFAs were most effective. Dietary interventions can be effective even when introduced in mature, high-risk animals and may be of benefit in reducing risk of sudden cardiac death.
P L McLennan; M Y Abeywardena; J S Charnock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  51     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-22     Completed Date:  1990-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  AIM; IM    
CSIRO Division of Human Nutrition, Glenthorne Laboratory, Australia.
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MeSH Terms
Age Factors
Dietary Fats / adverse effects*
Dietary Fats, Unsaturated / pharmacology*
Fatty Acids, Unsaturated / administration & dosage*
Fish Oils / administration & dosage
Food, Fortified
Plant Oils / administration & dosage
Rats, Inbred Strains
Ventricular Fibrillation / chemically induced*,  mortality,  prevention & control
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Plant Oils; 8001-21-6/sunflower seed oil

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