Document Detail

Reversal of an antihistamine-induced coma with flumazenil.
MedLine Citation:
PMID:  15123905     Owner:  NLM     Status:  MEDLINE    
Flumazenil is a competitive antagonist with specific action at the central benzodiazepine receptor. It is used when benzodiazepine intoxication is suspected. Its use has also been reported in cannabis intoxication, chloral hydrate overdose, hepatic encephalopathy, and alcohol intoxication. We report the case of a 7-month-old male infant with a depressed level of consciousness after intentional intoxication of antihistamines, whose mental status fully recovered after administration of flumazenil. To our knowledge, this is the first case in children where flumazenil has been reported to reverse antihistamine-induced coma.
Alvaro Lassaletta; Ricardo Martino; Pilar Gónzalez-Santiago; Carmen Torrijos; Margarita Cebrero; Enrique García-Frías
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric emergency care     Volume:  20     ISSN:  1535-1815     ISO Abbreviation:  Pediatr Emerg Care     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-04     Completed Date:  2004-06-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8507560     Medline TA:  Pediatr Emerg Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-20     Citation Subset:  IM    
Department of Pediatrics, Príncipe de Asturias University Hospital, Alcalá de Henares, Madrid, Spain.
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MeSH Terms
Child Abuse
Coma / chemically induced,  drug therapy*
Diphenhydramine / blood,  poisoning*,  urine
Flumazenil / therapeutic use*
Histamine H1 Antagonists / poisoning*
Hypnotics and Sedatives / poisoning*
Receptors, GABA-A / antagonists & inhibitors*
Trimeprazine / blood,  pharmacokinetics,  poisoning*,  urine
Reg. No./Substance:
0/Histamine H1 Antagonists; 0/Hypnotics and Sedatives; 0/Receptors, GABA-A; 58-73-1/Diphenhydramine; 78755-81-4/Flumazenil; 84-96-8/Trimeprazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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