Document Detail

Reversal agents in sedation and anesthesia: a review.
MedLine Citation:
PMID:  3137841     Owner:  NLM     Status:  MEDLINE    
This paper reviews the use of prototypic drugs for reversal of the effects produced by anesthetic and sedative agents. Efficacy and toxicity information is presented for naloxone (as used to reverse opioids), physostigmine (as used for reversal of sedatives), and Flumazenil (a new specific benzodiazepine receptor antagonist). Naloxone is very useful and specific for reversing adverse and life-threatening respiratory depression caused by narcotic drugs and should be used in these situations. Physostigmime has been advocated in incremental doses for reversing sedative effects in patients who are obtunded or depressed after having received benzodiazepines, droperidol, scopolamine, opioids, and phenothiazines. Flumazenil has been shown to readily antagonize the sedative, respiratory depressant, anxiolytic, muscle relaxant, anticonvulsant, amnestic, and anesthetic effects of the benzodiazepines; it appears to have tremendous potential for use in anesthesia, conscious sedation, and emergency medicine when available.
J A Anderson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia progress     Volume:  35     ISSN:  0003-3006     ISO Abbreviation:  Anesth Prog     Publication Date:    1988 Mar-Apr
Date Detail:
Created Date:  1988-10-06     Completed Date:  1988-10-06     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0043533     Medline TA:  Anesth Prog     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-7     Citation Subset:  D    
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MeSH Terms
Anesthesia / adverse effects*
Flumazenil / therapeutic use*
Naloxone / therapeutic use*
Physostigmine / therapeutic use*
Reg. No./Substance:
465-65-6/Naloxone; 57-47-6/Physostigmine; 78755-81-4/Flumazenil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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