Document Detail

Reversal of acute renal failure using hemodilution with hydroxyethyl starch.
MedLine Citation:
PMID:  6194306     Owner:  NLM     Status:  MEDLINE    
Acute renal failure (ARF) was induced in two groups of unilaterally nephrectomized dogs by occluding the renal artery, vein, and ureter of the remaining kidney for 2 hours. The control group (Group I), had no therapy; in the experimental group (Group II), isovolemic hemodilution was carried out using 6% hydroxy ethyl starch (HES) as diluent. The hematocrit in the experimental animals was lowered from 41.62 +/- 3.6% to 23.75 +/- 5.2% after renal occlusion. The mean arterial pressure and the mean pulmonary arterial pressure were unchanged in either group. Cardiac output increased following hemodilution from 1.66 +/- 0.35 to 2.70 +/- 0.50 L/min while it remained unchanged in Group I. Control animals developed ARF characterized by progressive rise in serum creatinine concentration and death. Only 1/7 Group I animals was alive on day 7 compared to 7/7 of Group II (p less than 0.01). ARF that developed initially in Group II began to resolve after day 4. There was a progressive and significant fall in serum creatinine concentration from 6.48 +/- 0.67 mg/dl on day 4 to 4.08 +/- 0.83 mg/dl on day 7 (p less than 0.001). Immediate isovolemic hemodilution with HES can reverse ARF induced by ischemia.
P R Rajagopalan; H D Reines; C Pulliam; C T Fitts; H H LeVeen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  23     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  795-800     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Creatinine / blood
Hetastarch / therapeutic use*
Ischemia / complications
Kidney / blood supply
Kidney Failure, Acute / therapy*
Pulmonary Artery
Starch / analogs & derivatives*
Time Factors
Reg. No./Substance:
60-27-5/Creatinine; 9005-25-8/Starch; 9005-27-0/Hetastarch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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