Document Detail

Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans.
MedLine Citation:
PMID:  20837997     Owner:  NLM     Status:  MEDLINE    
Animals search for foods and decide their behaviors according to previous experience. Caenorhabditis elegans detects chemicals with a limited number of sensory neurons, allowing us to dissect roles of each neuron for innate and learned behaviors. C. elegans is attracted to salt after exposure to the salt (NaCl) with food. In contrast, it learns to avoid the salt after exposure to the salt without food. In salt-attraction behavior, it is known that the ASE taste sensory neurons (ASEL and ASER) play a major role. However, little is known about mechanisms for learned salt avoidance. Here, through dissecting contributions of ASE neurons for salt chemotaxis, we show that both ASEL and ASER generate salt chemotaxis plasticity. In ASER, we have previously shown that the insulin/PI 3-kinase signaling acts for starvation-induced salt chemotaxis plasticity. This study shows that the PI 3-kinase signaling promotes aversive drive of ASER but not of ASEL. Furthermore, the Gq signaling pathway composed of Gqα EGL-30, diacylglycerol, and nPKC (novel protein kinase C) TTX-4 promotes attractive drive of ASER but not of ASEL. A putative salt receptor GCY-22 guanylyl cyclase is required in ASER for both salt attraction and avoidance. Our results suggest that ASEL and ASER use distinct molecular mechanisms to regulate salt chemotaxis plasticity.
Takeshi Adachi; Hirofumi Kunitomo; Masahiro Tomioka; Hayao Ohno; Yoshifumi Okochi; Ikue Mori; Yuichi Iino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-13
Journal Detail:
Title:  Genetics     Volume:  186     ISSN:  1943-2631     ISO Abbreviation:  Genetics     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-15     Completed Date:  2011-05-11     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1309-19     Citation Subset:  IM    
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo, Japan.
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MeSH Terms
Avoidance Learning
Behavior, Animal
Caenorhabditis elegans / metabolism*
Caenorhabditis elegans Proteins / metabolism*
Food Preferences*
GTP-Binding Protein alpha Subunits, Gq-G11 / metabolism*
Insulin / metabolism*
Protein Kinase C / metabolism
Sensory Receptor Cells
Signal Transduction*
Sodium Chloride*
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Insulin; 7647-14-5/Sodium Chloride; EC Kinase C; EC Protein alpha Subunits, Gq-G11

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