Document Detail


Reversal of Paclitaxel Resistance in Epithelial Ovarian Carcinoma Cells by a MUC1 Aptamer-let-7i Chimera.
MedLine Citation:
PMID:  22812695     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purpose of this study was to establish tumor tissue specific delivery of let-7i miRNA to reverse paclitaxel-induced chemoresistance. A chimera that combines MUC1 aptamer and let-7i miRNA was tested in OVCAR-3 ovarian cancer cells. Results demonstrated that the chimera can specifically be delivered into OVCAR-3 cells and the released let-7i significantly sensitized the role of paclitaxel in inhibiting cell proliferation, inducing cell apoptosis, and decreasing long-term cell survival. The chimera achieved reversal of chemoresistance through downregulation of cyclin D1, cyclin D2, Dicer 1, and PGRMC1 expressions. Our study indicated that this MUC1/let-7i chimera can specifically reverse chemoresistance to paclitaxel.
Authors:
Nenghui Liu; Changju Zhou; Jingfeng Zhao; Yuxiang Chen
Related Documents :
11934305 - Passaging protocols for mammalian neural stem cells in suspension bioreactors.
19964075 - Distribution of traction forces associated with shape changes during amoeboid cell migr...
17825085 - Involvements of a novel protein, dia2, in camp signaling and spore differentiation duri...
22555805 - Increased aldehyde reductase expression mediates acquired radioresistance of laryngeal ...
25364905 - Sclerotium rolfsii lectin induces stronger inhibition of proliferation in human breast ...
24259225 - Selenium retention and inhibition of cell growth in mouse mammary epithelial cell lines...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-19
Journal Detail:
Title:  Cancer investigation     Volume:  -     ISSN:  1532-4192     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307154     Medline TA:  Cancer Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynaecology, Xiangya Hospital,1.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging ...
Next Document:  Epoxidation of Olefins with a Silica-Supported Peracid.