Document Detail

Reversal of LPS-induced immobility in mice by green tea polyphenols: possible COX-2 mechanism.
MedLine Citation:
PMID:  15478205     Owner:  NLM     Status:  MEDLINE    
An endotoxin (lipopolysaccharide, LPS) is known to activate the hypothalamo-pituitary adrenocortical axis, as well as norepinephrine and indolamine metabolism. Systemically administered LPS produces depression in the forced swimming-induced despair behaviour model in mice. The present study was designed to investigate the effect of green tea extract (GTE) on LPS-induced despair behaviour and to explore the mechanism involved in modulation of LPS-induced immobility by GTE. GTE (10-100 mg/kg) pretreatment reversed LPS-induced immobility in a dose-dependent manner. Rofecoxib (2 mg/kg) and nimesulide (2 mg/kg), COX-2 inhibitors, also reversed the LPS-induced immobility, which was significantly potentiated by concomitant administration of GTE. On the other hand, GTE did not show any potentiating effect on immobility with naproxen (10 mg/kg), which is a nonselective COX blocker. Interestingly the antioxidant, carvedilol (2 mg/kg) did not produce any effect on immobility either in normal or in LPS treated mice. The results of the study implicate the role of COX-2 inhibition by GTE in the reversal of LPS-induced immobility.
Anjali Singal; Naveen Tirkey; Kanwaljit Chopra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  18     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-18     Completed Date:  2004-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  723-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 John Wiley & Sons, Ltd.
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India.
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MeSH Terms
Antidepressive Agents / administration & dosage,  pharmacology*,  therapeutic use
Behavior, Animal / drug effects
Cyclooxygenase 2
Dose-Response Relationship, Drug
Enzyme Inhibitors / administration & dosage,  pharmacology*,  therapeutic use
Flavonoids / administration & dosage,  pharmacology,  therapeutic use
Isoenzymes / antagonists & inhibitors*
Lipopolysaccharides / diagnostic use
Phenols / administration & dosage,  pharmacology,  therapeutic use
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Prostaglandin-Endoperoxide Synthases
Reg. No./Substance:
0/Antidepressive Agents; 0/Enzyme Inhibitors; 0/Flavonoids; 0/Isoenzymes; 0/Lipopolysaccharides; 0/Phenols; 0/Plant Extracts; 0/Tea; 0/polyphenols; EC 2; EC Synthases

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