| Revascularization of peripheral nerve autografts and allografts. | |
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MedLine Citation:
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PMID: 10597688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The timing and mechanisms of peripheral nerve revascularization were investigated using a 2-cm sciatic nerve graft model in 58 rats. Epineurial perfusion was consistently established by 48 hours and endoneurial perfusion by 72 hours. The pattern of endoneurial perfusion was "all-or-none"--either all or none of the vessels in a fascicle exhibited blood flow. Conventional allografts exhibited similar revascularization dynamics and patterns. Capping the ends of the autograft with Silastic significantly delayed revascularization; no flow was observed at 4 days, and only a peripheral rim of perfused fascicular vessels was observed at 7 days. These patterns suggested that the primary method of revascularization in the conventional graft was longitudinal inosculation; no evidence of peripheral neovascularization or dependence on the graft bed as a source of revascularization was observed. The introduction of a major histocompatibility complex barrier between the grafted tissue and the recipient animal did not alter the timing or the mechanics of blood flow reestablishment. |
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Authors:
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T J Best; S E Mackinnon; R Midha; D A Hunter; P J Evans |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Plastic and reconstructive surgery Volume: 104 ISSN: 0032-1052 ISO Abbreviation: Plast. Reconstr. Surg. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 2000-01-05 Completed Date: 2000-01-05 Revised Date: 2011-02-16 |
Medline Journal Info:
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Nlm Unique ID: 1306050 Medline TA: Plast Reconstr Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 152-60 Citation Subset: AIM; IM |
Affiliation:
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Institute of Medical Science, Department of Surgery, University of Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dimethylpolysiloxanes Male Random Allocation Rats Rats, Inbred Lew Rats, Inbred WF Sciatic Nerve / blood supply*, transplantation* Silicones Transplantation, Autologous Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Dimethylpolysiloxanes; 0/Silicones; 63148-62-9/baysilon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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