Document Detail

Revascularization for acute myocardial infarction. Strategies in need of revision.
MedLine Citation:
PMID:  2203557     Owner:  NLM     Status:  MEDLINE    
Prompt reperfusion of the ischemic myocardium by the successful use of thrombolytic agents in the setting of acute myocardial infarction has substantially reduced mortality among patients judged eligible for their use. This approach has revolutionized the management of acute infarction patients worldwide. Such therapy, however, is associated with increased rates of reinfarction and postinfarction angina that have been attributed to the underlying residual atherosclerotic lesion. The expectation that coronary angioplasty would provide the logical solution to this clinical problem has been considerably lowered by the results of a number of prospective randomized clinical trials. These findings, coupled with the realization that as many as 50% of patients suffering acute infarctions will not safely qualify for the use of thrombolytic agents, present compelling reasons to more accurately investigate the role of primary angioplasty and bypass surgery as a means of effecting reperfusion therapy in the setting of acute infarction.
T J Ryan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Circulation     Volume:  82     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-09     Completed Date:  1990-10-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  II110-6     Citation Subset:  AIM; IM    
Evans Memorial Department of Clinical Research, University Hospital, Boston, Mass 02118.
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MeSH Terms
Acute Disease
Angioplasty, Transluminal, Percutaneous Coronary
Coronary Artery Bypass
Myocardial Infarction / surgery*,  therapy
Myocardial Reperfusion
Myocardial Revascularization*

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