| Reusable tubular membrane oxygenator for isolated organ hemoperfusion. | |
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MedLine Citation:
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PMID: 931867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A reusable tubular membrane oxygenator is described for hypotraumatic hemoperfusion of isolated organs in physiological studies. The constructed oxygenator was of approximately 0.24-m2 effective surface area and contained 450 silicone rubber capillaries of 0.51-mm nominal ID, 34.9 cm long, fixed by conical-shaped, plastic blood headers at manifolds made from Dow-Corning MDX-4-4210 silicone elastomer. During ex vivo hemoperfusions in dogs at inlet hemoglobin saturations near 67%, oxygen transfer rates of the oxygenator increased serially, from 16.6 +/- 1.7 ml/min per m2 (mean +/- SD) at blood flows of 100 ml/min to 34.1 +/- 3.8 ml/min per m2 at flows of 500 ml/min. The oxygenator was thromboresistant and of much loss priming blood volume and wall compliance than the nonresuable Travenol membrane oxygenator of 0.26-m2 effective surface area. The tubular oxygenator was easily cleaned and reassembled, with reproducible oxygen transfer rates. It should prove useful for hemoperfusion studies in organs of moderate size, such as the isolated canine kidney, stomach, and pancreas. |
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Authors:
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W H Waugh; T E Bales; H Nihei |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology Volume: 40 ISSN: 0021-8987 ISO Abbreviation: J Appl Physiol Publication Date: 1976 Mar |
Date Detail:
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Created Date: 1976-09-01 Completed Date: 1976-09-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376576 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 476-82 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Carbon Dioxide Dogs Oxygen Oxygenators, Membrane / instrumentation* Perfusion / instrumentation* Silicone Elastomers |
| Chemical | |
Reg. No./Substance:
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0/Silicone Elastomers; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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