Document Detail

Return of fertility after autologous stem cell transplantation.
MedLine Citation:
PMID:  11821109     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study cases where bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT)-induced menopause was entirely reversed. DESIGN: Retrospective analysis. SETTING: An inpatient BMT unit and an ambulatory fertility center in a university hospital. PATIENT(S): Two patients with Hodgkin's disease and two with advanced breast carcinoma requiring stem cell transplantation. INTERVENTION(S): Estrogen treatment, monitoring of follicle-stimulating hormone (FSH) and estradiol (E(2)) levels, and, ultimately, monitoring of pregnancy. MAIN OUTCOME MEASURE(S): Pregnancy. RESULT(S): All four patients established pregnancies, but two of them elected to terminate due to the use of tamoxifen early in pregnancy. CONCLUSION(S): Menopausal changes resulting from BMT may spontaneously reverse, with reestablishment of normal hormonal function and viable pregnancies.
Avner Hershlag; Michael W Schuster
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  77     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-31     Completed Date:  2002-03-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  419-21     Citation Subset:  IM    
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, North Shore University Hospital-New York University School of Medicine, 300 Community Drive, Manhasset, NY 11030, USA.
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MeSH Terms
Antineoplastic Agents, Hormonal / adverse effects,  therapeutic use
Bone Marrow Transplantation / physiology*
Breast Neoplasms / therapy
Carcinoma, Ductal, Breast / therapy
Fertility / physiology*
Hematopoietic Stem Cell Transplantation*
Hodgkin Disease / therapy
Hormone Replacement Therapy
Retrospective Studies
Tamoxifen / adverse effects,  therapeutic use
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 10540-29-1/Tamoxifen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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