| Rett syndrome: presumptive carriers of the gene defect. Sex ratio among their siblings. | |
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MedLine Citation:
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PMID: 9452931 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The live-born full siblings of 121 presumptive carriers of Rett syndrome belonging to eight pedigrees were examined as to sex ratio at birth. A total of 394 such siblings born in the period 1757-1966 were identified. 183 (46.4%) of them were male and 211 (53.6%) female, i.e., significantly fewer than in the average Swedish population (p = 0.03) were male. Our findings support the existence of one or more lethal alleles causing Rett syndrome. |
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Authors:
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H O Akesson; B Hagberg; J Wahlström |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European child & adolescent psychiatry Volume: 6 Suppl 1 ISSN: 1018-8827 ISO Abbreviation: Eur Child Adolesc Psychiatry Publication Date: 1997 |
Date Detail:
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Created Date: 1998-05-06 Completed Date: 1998-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9212296 Medline TA: Eur Child Adolesc Psychiatry Country: GERMANY |
Other Details:
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Languages: eng Pagination: 101-2 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Sahlgren University Hospital, Göteborg, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Binomial Distribution Confidence Intervals Female Genes, Lethal Heterozygote* Humans Male Nuclear Family Pedigree Retrospective Studies Rett Syndrome / epidemiology, genetics* Sex Ratio* Sweden / epidemiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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