Document Detail

Retrovirus from human T-cell leukemia virus type I-associated myelopathy is the same strain as a prototype human T-cell leukemia virus type I.
MedLine Citation:
PMID:  2241626     Owner:  NLM     Status:  MEDLINE    
A retrovirus was isolated from a T-cell line that was established from lymphocytes in the cerebrospinal fluid of a patient with human T-cell leukemia virus type I-associated myelopathy (HAM), and its genome was sequenced. The nucleotide sequence of the 3' half of the total genome was identical in 99.5% of the nucleotides to that of the prototype human T-cell leukemia virus type I that was derived from a patient with adult T-cell leukemia. These results indicate that the same retrovirus human T-cell leukemia virus type I is associated with both a neurological disease, HAM, and a lymphoproliferative disease, adult T-cell leukemia.
S Shirabe; T Nakamura; M Tsujihata; S Nagataki; M Seiki; M Yoshida
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  47     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-14     Completed Date:  1990-12-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1258-60     Citation Subset:  AIM; IM; X    
Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
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MeSH Terms
Amino Acid Sequence
Base Sequence
DNA, Viral / analysis
Genes, Viral
Human T-lymphotropic virus 1 / genetics,  isolation & purification*
Leukemia-Lymphoma, Adult T-Cell / microbiology
Middle Aged
Molecular Sequence Data
Paraparesis, Tropical Spastic / microbiology*
Proviruses / genetics,  isolation & purification
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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