Document Detail

Retroviral capsid determinants of Fv1 NB and NR tropism.
MedLine Citation:
PMID:  15331691     Owner:  NLM     Status:  MEDLINE    
The specificity determinants for susceptibility to resistance by the Fv1 n and b alleles map to amino acid 110 of the murine leukemia virus CA protein. To study the interaction between Fv1 and CA, we examined changes in CA resulting in the loss of susceptibility to Fv1 resistance in naturally occurring NB- and NR-tropic viruses. A variety of amino acid changes affecting Fv1 tropism were identified, at CA positions 82, 92 to 95, 105, 114, and 117, and they all were mapped to the apparent exterior of virion-associated CA. These amino acids may form a binding surface for Fv1.
Anthony Stevens; Michael Bock; Scott Ellis; Paul LeTissier; Kate N Bishop; Melvyn W Yap; Willie Taylor; Jonathan P Stoye
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of virology     Volume:  78     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-27     Completed Date:  2004-09-28     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9592-8     Citation Subset:  IM    
Copyright Information:
Copyright 2004 American Society for Microbiology
Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom.
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MeSH Terms
Amino Acid Sequence
BALB 3T3 Cells
Base Sequence
Binding Sites
Capsid Proteins / chemistry,  genetics*,  physiology
Cell Line
DNA / genetics
DNA, Viral / genetics
Genes, Viral
Leukemia Virus, Murine / genetics*,  isolation & purification,  pathogenicity*
Models, Molecular
Molecular Sequence Data
NIH 3T3 Cells
Proteins / genetics*,  physiology
Virulence / genetics
Reg. No./Substance:
0/Capsid Proteins; 0/DNA, Viral; 0/Fv1 protein, mouse; 0/Proteins; 9007-49-2/DNA

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