Document Detail

Retrosplenial cortical activation in the fibromyalgia syndrome.
MedLine Citation:
PMID:  12657898     Owner:  NLM     Status:  MEDLINE    
To study the CNS in chronic muscular pain typical of fibromyalgia we compared PET measures of regional cerebral blood flow (rCBF) in eight fibromyalgic patients and controls at rest. Higher rCBF for patients than controls was found bilaterally in the retrosplenial cortex. Lower rCBF for patients than controls were seen in the left frontal, temporal, parietal, and occipital cortices. The higher retroplenial rCBF in patients than controls may reflect increased attention towards sub-noxious somatosensory signaling, and agrees with the notion that fibromyalgic pain reflects secondary hyperalgesia. The brain regions with lower rCBF in fibromyalgic patients than controls participate in the normal cognitive processing of pain, which may be dysfunctional in fibromyalgia.
Gustav Wik; Håkan Fischer; Björn Bragée; Marianne Kristianson; Mats Fredrikson
Related Documents :
401638 - Sodium valproate and clonazepam in the treatment of intractable epilepsy.
15256188 - Effects of epilepsy on autonomic nervous system and respiratory function tests.
17345038 - Clinical and magnetic resonance imaging findings of hiv-negative patients with neurosyp...
11775258 - Brain mri of hippocampal volumetry in patients with refractory temporal lobe epilepsy.
11296098 - Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-in...
2680358 - Hematologic manifestations of malignancy.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  14     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  619-21     Citation Subset:  IM    
Department of Psychiatry, University of Bergen, Sandviken Hospital, N-5035, Bergen, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Mapping
Cerebral Cortex / physiopathology*
Dominance, Cerebral*
Fibromyalgia / physiopathology*
Hyperalgesia / etiology
Middle Aged
Photic Stimulation
Regional Blood Flow
Tomography, Emission-Computed / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression and regulation of mPer1 in immortalized GnRH neurons.
Next Document:  Circuitry of rat barrel cortex investigated by infrared-guided laser stimulation.