Document Detail


Retrosplenial cortical activation in the fibromyalgia syndrome.
MedLine Citation:
PMID:  12657898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To study the CNS in chronic muscular pain typical of fibromyalgia we compared PET measures of regional cerebral blood flow (rCBF) in eight fibromyalgic patients and controls at rest. Higher rCBF for patients than controls was found bilaterally in the retrosplenial cortex. Lower rCBF for patients than controls were seen in the left frontal, temporal, parietal, and occipital cortices. The higher retroplenial rCBF in patients than controls may reflect increased attention towards sub-noxious somatosensory signaling, and agrees with the notion that fibromyalgic pain reflects secondary hyperalgesia. The brain regions with lower rCBF in fibromyalgic patients than controls participate in the normal cognitive processing of pain, which may be dysfunctional in fibromyalgia.
Authors:
Gustav Wik; Håkan Fischer; Björn Bragée; Marianne Kristianson; Mats Fredrikson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  14     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-26     Completed Date:  2003-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  619-21     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Bergen, Sandviken Hospital, N-5035, Bergen, Norway. gustav.wik@psyk.uib.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping
Cerebral Cortex / physiopathology*
Dominance, Cerebral*
Female
Fibromyalgia / physiopathology*
Humans
Hyperalgesia / etiology
Middle Aged
Photic Stimulation
Regional Blood Flow
Tomography, Emission-Computed / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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