| Retrospective study of ketotifen protective action in different allergopathies. | |
| | |
MedLine Citation:
|
PMID: 3328514 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
There is no doubt that ketotifen has continued to be an effective prophylactic anti-allergic drug throughout the years since its discovery. Therefore, we decided to perform a retrospective study of this pharmacologic agent to evaluate its efficacy, duration of treatment, as well as its tolerance in different allergic processes. A total of 1,000 histories of allergic patients were reviewed and 450 were selected by chance from 1981 through 1984. The patients were divided as to their diagnostic etiology, whether affected by pollen or house dust. Ketotifen efficacy was graded from 0-3 (bad, regular, good and excellent), according to its clinical evaluation. In general, children responded better to ketotifen treatment than adults (reduction in other symptomatic drug intake), although statistical significance was found in both populations. However, drug efficacy was better in pollen than house dust. Induced asthma and rhinitis in the children population. On the other hand, no statistical difference was found between sensitization to house dust or pollens in the adult population. To be truly effective, ketotifen should be taken for at least 3 months or more. We only found 12 (2.66%) patients who presented somnolence: the rest tolerated the drug well, with no secondary side effects. |
| | |
Authors:
|
M Fernández; E Wong; A Oehling |
Related Documents
:
|
19126374 - Chronic migraine: current pathophysiologic concepts as targets for treatment. 18093034 - Pharmaceutical treatment of asthma symptoms in elite athletes - doping or therapy? 15002754 - Usefulness of bronchial reactivity analysis in the diagnosis of bronchial asthma in pat... 15891414 - Preventive treatment of headaches. 21283494 - The use of cimetidine in hospitalized patients. 23270784 - Predictive methods in drug repurposing: gold mine or just a bigger haystack? |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Allergologia et immunopathologia Volume: 15 ISSN: 0301-0546 ISO Abbreviation: Allergol Immunopathol (Madr) Publication Date: 1987 Nov-Dec |
Date Detail:
|
Created Date: 1988-05-10 Completed Date: 1988-05-10 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370073 Medline TA: Allergol Immunopathol (Madr) Country: SPAIN |
Other Details:
|
Languages: eng Pagination: 369-73 Citation Subset: IM |
Affiliation:
|
Department of Allergology, Faculty of Medicine, University of Navarra, Pamplona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Child Clinical Trials as Topic Drug Tolerance Humans Hypersensitivity / drug therapy, prevention & control* Ketotifen / adverse effects, therapeutic use* Retrospective Studies Rhinitis, Allergic, Perennial / drug therapy, prevention & control Rhinitis, Allergic, Seasonal / drug therapy, prevention & control Sleep Stages / drug effects |
| Chemical | |
Reg. No./Substance:
|
34580-13-7/Ketotifen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The evaluation of immediate hypersensitivity reactions: current concepts and future directions.
Next Document: Eosinophilic gastroenteritis: a description of a new case with serous affectation.