Document Detail


Retrospective review of diagnostic performance of intracranial translucency in the detection of open spina bifida at the 11-13 week scan.
MedLine Citation:
PMID:  21404357     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate (1) diagnostic performance of intracranial translucency (IT) for detection of open spina bifida (SB) and (2) interobserver agreement for visualization of IT during the 11-13 week scan. METHODS: This is a retrospective study in a tertiary referral centre. Two hundred 11-13 week nuchal translucency scans performed by Fetal Medicine Foundation UK certified sonographers were independently reviewed by two experienced observers for IT. When IT was not seen, observers determined the reason: poor IT image quality or SB. Discordant cases were reviewed by a third observer and the majority decision used for analysis. All observers were blinded to individual pregnancy outcome and number of cases with SB. RESULTS: There were 191 normal fetuses, 8 with open SB and 1 with closed SB (this case was excluded from analysis). IT was seen in 150 fetuses and all were normal. In 6 of the 49 cases where IT was not seen, IT non-visibility was attributed to open SB; among these, 4 fetuses had open SB and 2 were normal. In the remaining 43 cases (including 39 normal fetuses), IT non-visibility was attributed to inadequate image quality. Sensitivity was 50% (4/8), specificity 99% (150/152). Concordance between the two readers for IT visibility was 79%, (κ = 0.47, representing moderate agreement). CONCLUSION: There was moderate interobserver agreement for visualization of IT on images obtained for nuchal translucency at 11-13 weeks. When IT was confidently seen, open SB could be excluded. However, non-visibility of IT correctly diagnosed only 50% of fetuses with open SB. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
K W Fong; A Toi; N Okun; E Al-Shami; R J Menezes
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-14
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Department of Medical Imaging, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. kfong@mtsinai.on.ca.
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