| Retrospective review of diagnostic performance of intracranial translucency in the detection of open spina bifida at the 11-13 week scan. | |
| | |
MedLine Citation:
|
PMID: 21404357 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: To evaluate (1) diagnostic performance of intracranial translucency (IT) for detection of open spina bifida (SB) and (2) interobserver agreement for visualization of IT during the 11-13 week scan. METHODS: This is a retrospective study in a tertiary referral centre. Two hundred 11-13 week nuchal translucency scans performed by Fetal Medicine Foundation UK certified sonographers were independently reviewed by two experienced observers for IT. When IT was not seen, observers determined the reason: poor IT image quality or SB. Discordant cases were reviewed by a third observer and the majority decision used for analysis. All observers were blinded to individual pregnancy outcome and number of cases with SB. RESULTS: There were 191 normal fetuses, 8 with open SB and 1 with closed SB (this case was excluded from analysis). IT was seen in 150 fetuses and all were normal. In 6 of the 49 cases where IT was not seen, IT non-visibility was attributed to open SB; among these, 4 fetuses had open SB and 2 were normal. In the remaining 43 cases (including 39 normal fetuses), IT non-visibility was attributed to inadequate image quality. Sensitivity was 50% (4/8), specificity 99% (150/152). Concordance between the two readers for IT visibility was 79%, (κ = 0.47, representing moderate agreement). CONCLUSION: There was moderate interobserver agreement for visualization of IT on images obtained for nuchal translucency at 11-13 weeks. When IT was confidently seen, open SB could be excluded. However, non-visibility of IT correctly diagnosed only 50% of fetuses with open SB. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
| | |
Authors:
|
K W Fong; A Toi; N Okun; E Al-Shami; R J Menezes |
Related Documents
:
|
16549507 - Amplified immunohistochemical detection of prpsc in animal transmissible spongiform enc... 12913427 - A case of human thelaziasis in seoul. 16513497 - Rickettsia felis, the agent of an emerging infectious disease: report of a new case in ... 19161717 - Long-term cryptosporidium typing reveals the aetiology and species-specific epidemiolog... 21791717 - Hypebaric oxygen treatment in urology. 3751567 - Minimal change renal disease associated with thymoma and pancreatic carcinoma. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-14 |
Journal Detail:
|
Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: - ISSN: 1469-0705 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Medical Imaging, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. kfong@mtsinai.on.ca. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of 4D ultrasound (STIC + sonoAVC) in the prenatal assessment of atrial morphology cardiospl...
Next Document: Exploring sequence requirements for C(3) /C(4) carboxylate recognition in the Pseudomonas aeruginosa...