Document Detail


Retrospective review of the clinical manifestations and outcomes in Puerto Ricans with idiopathic inflammatory myopathies.
MedLine Citation:
PMID:  16357735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of conditions characterized by chronic inflammation of muscles, resulting in skeletal muscle weakness. Racial differences are apparent in the clinical manifestations and outcome of IIM. No previous studies have been conducted to evaluate the clinical manifestations and outcome of Puerto Ricans with IIM. OBJECTIVE: The objective of this study was to describe demographic characteristics, clinical features, and functional outcome of Puerto Rican patients with IIM. METHODS: Medical records at a university medical center were reviewed retrospectively to collect data regarding demographic factors, initial presentation, diagnostic tests, serologic markers, treatment, and disease course. A Functional Grading Scale was administered to 40 of the patients with IIM to determine their functional status. RESULTS: Fifty patients with IIM were identified. Eight patients had polymyositis (PM), 23 patients had dermatomyositis (DM), 2 patients had DM/PM with coexistent malignancy, 12 patients had juvenile DM, and 5 patients had DM/PM with an associated other rheumatologic disease. At diagnosis, proximal muscle weakness was present in all patients, 15 (30%) had myalgias, 5 (10%) patients had dysphagia, and 87% had elevation of serum muscle enzymes. Visceral involvement was rare. Interstitial fibrosis was identified in only 2 patients (1 juvenile DM and 1 PM). Twenty-six patients (51%) achieved complete remission. The mean score for the Functional Grading Scale was 28.6 (maximum 30). The lowest scores were seen for patients with disease duration of less than 2 years. CONCLUSION: Puerto Ricans with IIM in this survey showed a low presence of visceral involvement, high remission rate, and low mortality.
Authors:
Grissel Ríos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  11     ISSN:  1076-1608     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-12-16     Completed Date:  2006-02-07     Revised Date:  2008-04-10    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
Affiliation:
Division of Rheumatology, Department of Medicine, University of Puerto Rico, San Juan, Puerto Rico. grios@rcm.upr.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Inflammatory Agents / therapeutic use
Antibodies, Antinuclear / blood
Arthritis, Rheumatoid / complications
Biopsy
Blood Sedimentation
Calcinosis / etiology
Creatine Kinase / blood
Deglutition Disorders / etiology
Drug Therapy, Combination
Electromyography
Female
Fructose-Bisphosphate Aldolase / blood
Humans
Lupus Erythematosus, Systemic / complications
Male
Muscle Weakness / etiology
Muscle, Skeletal / pathology
Myositis / complications,  diagnosis*,  drug therapy
Pain / etiology
Prednisone / therapeutic use
Puerto Rico
Pulmonary Fibrosis / complications,  pathology
Remission Induction
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antibodies, Antinuclear; 53-03-2/Prednisone; EC 2.7.3.2/Creatine Kinase; EC 4.1.2.13/Fructose-Bisphosphate Aldolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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