| Retrospective review of the clinical manifestations and outcomes in Puerto Ricans with idiopathic inflammatory myopathies. | |
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MedLine Citation:
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PMID: 16357735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The idiopathic inflammatory myopathies (IIM) are a heterogeneous group of conditions characterized by chronic inflammation of muscles, resulting in skeletal muscle weakness. Racial differences are apparent in the clinical manifestations and outcome of IIM. No previous studies have been conducted to evaluate the clinical manifestations and outcome of Puerto Ricans with IIM. OBJECTIVE: The objective of this study was to describe demographic characteristics, clinical features, and functional outcome of Puerto Rican patients with IIM. METHODS: Medical records at a university medical center were reviewed retrospectively to collect data regarding demographic factors, initial presentation, diagnostic tests, serologic markers, treatment, and disease course. A Functional Grading Scale was administered to 40 of the patients with IIM to determine their functional status. RESULTS: Fifty patients with IIM were identified. Eight patients had polymyositis (PM), 23 patients had dermatomyositis (DM), 2 patients had DM/PM with coexistent malignancy, 12 patients had juvenile DM, and 5 patients had DM/PM with an associated other rheumatologic disease. At diagnosis, proximal muscle weakness was present in all patients, 15 (30%) had myalgias, 5 (10%) patients had dysphagia, and 87% had elevation of serum muscle enzymes. Visceral involvement was rare. Interstitial fibrosis was identified in only 2 patients (1 juvenile DM and 1 PM). Twenty-six patients (51%) achieved complete remission. The mean score for the Functional Grading Scale was 28.6 (maximum 30). The lowest scores were seen for patients with disease duration of less than 2 years. CONCLUSION: Puerto Ricans with IIM in this survey showed a low presence of visceral involvement, high remission rate, and low mortality. |
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Authors:
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Grissel Ríos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Volume: 11 ISSN: 1076-1608 ISO Abbreviation: J Clin Rheumatol Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-12-16 Completed Date: 2006-02-07 Revised Date: 2008-04-10 |
Medline Journal Info:
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Nlm Unique ID: 9518034 Medline TA: J Clin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 153-6 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Department of Medicine, University of Puerto Rico, San Juan, Puerto Rico. grios@rcm.upr.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anti-Inflammatory Agents / therapeutic use Antibodies, Antinuclear / blood Arthritis, Rheumatoid / complications Biopsy Blood Sedimentation Calcinosis / etiology Creatine Kinase / blood Deglutition Disorders / etiology Drug Therapy, Combination Electromyography Female Fructose-Bisphosphate Aldolase / blood Humans Lupus Erythematosus, Systemic / complications Male Muscle Weakness / etiology Muscle, Skeletal / pathology Myositis / complications, diagnosis*, drug therapy Pain / etiology Prednisone / therapeutic use Puerto Rico Pulmonary Fibrosis / complications, pathology Remission Induction Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Antibodies, Antinuclear; 53-03-2/Prednisone; EC 2.7.3.2/Creatine Kinase; EC 4.1.2.13/Fructose-Bisphosphate Aldolase |
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