Document Detail

Retrospective evaluation of serum markers APRI and AST/ALT for assessing liver fibrosis and cirrhosis in chronic hepatitis B and C patients with hepatocellular carcinoma.
MedLine Citation:
PMID:  18379139     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Aspartate aminotransferase-to-platelet ratio index (APRI), aspartate aminotransferase-to-alanine aminotransferase (AST/ALT) ratio, platelet count, AST, albumin, bilirubin and alkaline phosphatase were retrospectively evaluated for the prediction of advanced liver fibrosis and cirrhosis in patients with resectable hepatocellular carcinoma in this study. PATIENTS: In total, the 97 selected patients consisted of 9 (9.3%) patients with non-B, non-C chronic hepatitis, 48 (49.5%) patients with chronic hepatitis B (CHB) and 40 (41.2%) patients with chronic hepatitis C (CHC). RESULTS: The APRI, but not AST/ALT or other serum markers, showed a significant correlation with advanced liver fibrosis and cirrhosis (p<0.05). The area under receiver operating characteristic curves (AUROC) for predicting advanced fibrosis was 0.69 in CHB patients and 0.87 in CHC patients, whereas AUROC for predicting cirrhosis was 0.75 in CHB patients and 0.84 in CHC patients. In addition, the sensitivity and specificity of APRI were greater than 80% for predicting advanced fibrosis and cirrhosis in the CHC patients. CONCLUSION: APRI is a simple and non-invasive biochemical marker of liver fibrosis and cirrhosis, particularly in CHC patients. APRI potentially could be used to decrease the number of liver biopsies.
Chen-Sheng Lin; Chi-Sen Chang; Sheng-Shun Yang; Hong-Zen Yeh; Cheng-Wen Lin
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2008-04-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  47     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  569-75     Citation Subset:  IM    
Division of Gastroenterology, Taichung Veterans General Hospital, Taiwan.
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MeSH Terms
Alanine Transaminase / blood*
Aspartate Aminotransferases / blood*
Biological Markers / blood
Carcinoma, Hepatocellular / blood*,  complications,  enzymology
Hepatitis B, Chronic / blood,  complications,  enzymology
Hepatitis C, Chronic / blood,  complications,  enzymology
Hepatitis, Chronic / blood*,  complications,  enzymology
Liver Cirrhosis / blood*,  complications,  enzymology
Liver Function Tests
Liver Neoplasms / blood*,  complications,  enzymology
Middle Aged
Retrospective Studies
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; EC Aminotransferases; EC Transaminase

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