Document Detail

Retrospective diagnosis of hypoxic myocardial injury in premature newborns.
MedLine Citation:
PMID:  16602843     Owner:  NLM     Status:  MEDLINE    
Perinatal asphyxia has a high impact on neonatal mortality, morbidity, and neurological outcome. The hypoxic effects on brain, kidney and gastrointestinal system are well recognized in newborns. While it is known that hypoxia also effects cardiac function, there are few studies of quantitative myocardial injury in premature infants who suffered hypoxia. AIM: To investigate usefulness of cardiac troponin (cTnT) and creatinine kinase MB (CK-MB) in the diagnosis of myocardial injury due to birth hypoxia and to correlate these markers with cardiac functions as measured by echocardiogram. METHODS: We studied 43 preterm infants: 21 with birth asphyxia and 22 controls. Echocardiographic studies and quantitative determination of cTnT and CK-MB in blood serum was performed between the 12(th) and the 24(th) h of life. RESULTS: cTnT and CK-MB levels were higher in asphyxiated infants compared to controls (0.287 +/- 0.190 vs. 0.112 +/- 0.099 ng/mL, P < 0.001) and (18.35 +/-14.81 vs. 11.09 +/- 5.17 ng/L, P < 0.05). Among controls, we observed an elevated value of cTnT in those with respiratory distress syndrome (RDS). We found a decrease in fractional shortening (P < 0.05) and an increase in tricuspid insufficiency (P < 0.01) in asphyxiated newborns. CONCLUSIONS: cTnT and CK-MB levels are strong indicators of myocardial injury due to perinatal hypoxia. The cTnT level was most strongly related to RDS.
Marta Szymankiewicz; Marzena Matuszczak-Wleklak; Dharmapuri Vidyasagar; Janusz Gadzinowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  34     ISSN:  0300-5577     ISO Abbreviation:  J Perinat Med     Publication Date:  2006  
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-10-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  220-5     Citation Subset:  IM    
Department of Neonatology, Poznan University of Medical Sciences, Poland.
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MeSH Terms
Anoxia / blood,  complications*
Asphyxia Neonatorum / blood,  complications
Biological Markers / blood*
Case-Control Studies
Creatine Kinase, MB Form / blood*
Gestational Age
Heart / physiopathology
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / blood,  diagnosis
Myocardial Ischemia
Myocardium / pathology*
Predictive Value of Tests
ROC Curve
Respiratory Distress Syndrome, Newborn / blood
Troponin T / blood*
Reg. No./Substance:
0/Biological Markers; 0/Troponin T; EC Kinase, MB Form

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