| Retrospective comparison of magnetic resonance imaging features and histopathology in Crohn's disease patients. | |
| | |
MedLine Citation:
|
PMID: 21295932 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: To retrospectively compare histopathological findings of surgically resected bowel segments with magnetic resonance imaging (MRI) findings on Crohn's disease activity. MATERIALS AND METHODS: Patients who underwent a MR enterography or enteroclysis before surgery were included after informed consent. MRI features (T1-enhancement, T1 and T2 stratification, T2 signal intensity, bowel wall thickness, presence of ulcerations, comb sign, creeping fat, and disease activity) were assessed by three experienced abdominal radiologists. An acute inflammatory score based on histopathology (parameters: mucosal ulceration, edema, depth and degree of neutrophils) was calculated. Interobserver variability for subjective MRI features was also assessed. RESULTS: Thirty-nine segments in 25 patients (mean age 38 years) were included. Of the MRI features, disease activity per segment and bowel wall thickness had a positive association with the acute inflammatory score (p<0.05). T1-enhancement had a positive correlation with disease chronicity. All other MRI features did not have an association with the acute inflammatory score. Interobserver agreement between the three observers was weak to moderate. CONCLUSION: MR features bowel wall thickness and disease activity per-segment reflect disease activity in Crohn's disease patients. |
| | |
Authors:
|
Manon L W Ziech; Shandra Bipat; Joris J T H Roelofs; C Yung Nio; Banafsche Mearadji; Sascha van Doorn; Anje M Spijkerboer; Jaap Stoker |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-3 |
Journal Detail:
|
Title: European journal of radiology Volume: - ISSN: 1872-7727 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Academic Medical Center, Department of Radiology, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Peripheral MRA with continuous table movement: Imaging speed and robustness compared to a convention...
Next Document: Development of a quantitative PCR assay for residual mouse DNA and comparison of four sample purific...